Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670580 | 0.86 | TRPV1 (0.43) | MCHR1TRPV1ACP1KMT2AMEN1 | |
| SCHEMBL19670410 | 0.86 | TRPV1 (0.43) | MAPTADORA2AMCHR1TRPV1KMT2A | |
| SCHEMBL19670141 | 0.85 | SCN9A (0.37) | KDM4EADORA2AMCHR1TRPV1KMT2A | |
| SCHEMBL19670412 | 0.85 | POLB (0.37) | MAPTADORA2AMCHR1KMT2AMEN1 | |
| SCHEMBL17618413 | 0.84 | MAPT (0.44) | MAPTKDM4EPKMNPSR1RAB9A | |
| SCHEMBL19670214 | 0.83 | TRPA1 (0.38) | MAPTADORA2AKMT2AMEN1ALDH1A1 | |
| SCHEMBL19670135 | 0.83 | MEN1 (0.41) | MAPTKDM4EADORA2AMCHR1TRPV1 | |
| SCHEMBL19670425 | 0.83 | KMT2A (0.39) | MAPTKDM4EADORA2AMCHR1KMT2A | |
| SCHEMBL19670221 | 0.82 | UBE2M (0.37) | MAPTNPSR1ADORA2AKMT2AMEN1 | |
| SCHEMBL19670209 | 0.81 | CNR2 (0.36) | MAPTADORA2AKMT2AMEN1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |