Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670218 | 0.86 | MAPT (0.43) | TRPV1MCHR1KDM1AMAOAMAOB | |
| SCHEMBL19670141 | 0.86 | SCN9A (0.37) | TRPV1SCN9AMCHR1KDM1AMAOA | |
| SCHEMBL19670214 | 0.84 | TRPA1 (0.38) | CA2CA9KMOKDM1AMAOA | |
| SCHEMBL19670412 | 0.84 | POLB (0.37) | MCHR1KDM1ACHRM3CSF1RMEN1 | |
| SCHEMBL19670135 | 0.84 | MEN1 (0.41) | TRPV1CA2CA9KMOMCHR1 | |
| SCHEMBL16775889 | 0.84 | TRPV1 (0.40) | TRPV1CA2CA9HCRTR1HCRTR2 | |
| SCHEMBL19670410 | 0.83 | TRPV1 (0.43) | TRPV1CA2CA9MCHR1KDM1A | |
| SCHEMBL19670629 | 0.83 | CA2 (0.40) | TRPV1CA2CA9KMOCHRM3 | |
| SCHEMBL19670140 | 0.83 | TRPV1 (0.37) | TRPV1CA2CA9 | |
| SCHEMBL19670179 | 0.83 | HTR2C (0.46) | TRPV1CSF1RMEN1UBE2MKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |