Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365770 | 1.00 | ALDH1A1 (0.38) | ALDH1A1GSK3BDYRK1AABL1FAAH | |
| SCHEMBL19365410 | 0.86 | RAB9A (0.41) | GSK3BDYRK1AABL1MEN1HTT | |
| SCHEMBL19365409 | 0.86 | RAB9A (0.41) | GSK3BDYRK1AABL1MEN1HTT | |
| SCHEMBL16249991 | 0.85 | ALDH1A1 (0.38) | ALDH1A1GSK3BDYRK1AABL1FAAH | |
| SCHEMBL19365553 | 0.83 | CNR2 (0.42) | ALDH1A1GSK3BDYRK1AFAAHMEN1 | |
| SCHEMBL19670319 | 0.83 | FAAH (0.42) | GSK3BDYRK1AFAAHMEN1HTT | |
| SCHEMBL19365560 | 0.83 | CNR2 (0.42) | ALDH1A1GSK3BDYRK1AFAAHMEN1 | |
| SCHEMBL19364826 | 0.83 | FAAH (0.42) | GSK3BDYRK1AFAAHMEN1HTT | |
| SCHEMBL19365401 | 0.83 | MALT1 (0.40) | GSK3BDYRK1AFAAHCNR2RAB9A | |
| SCHEMBL19365400 | 0.83 | MALT1 (0.40) | GSK3BDYRK1AFAAHCNR2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |