Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CPT2 | P23786 | 1/20 | 0.36 |
| ▸ | CPT1A | P50416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365743 | 0.91 | THRB (0.40) | USP30SYKBRD4PDK1PDK2 | |
| SCHEMBL19365317 | 0.88 | GSK3B (0.39) | SYKPDK1PDK2PDK3PDK4 | |
| SCHEMBL19670420 | 0.88 | HDAC2 (0.42) | USP30BRD4PDK1PDK2PDK3 | |
| SCHEMBL19365613 | 0.88 | FAAH (0.40) | GSK3BDYRK1ACNR2 | |
| SCHEMBL19670153 | 0.85 | VCP (0.41) | GRM5GSK3BDYRK1ACNR2 | |
| SCHEMBL19670233 | 0.85 | FAAH (0.39) | USP30BRD4PDK1PDK2PDK3 | |
| SCHEMBL16775933 | 0.85 | USP30 (0.39) | USP30SYKGRM5MTORADORA2A | |
| SCHEMBL19365276 | 0.85 | WNT3A (0.41) | GRM5MTORGSK3BDYRK1A | |
| SCHEMBL19365517 | 0.84 | BRAF (0.40) | GRM5BRD4PDK1PDK2PDK3 | |
| SCHEMBL19670150 | 0.83 | IRAK4 (0.40) | GRM5GSK3BKCNH2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |