Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCP | P55072 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | TP53BP1 | Q12888 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365434 | 0.91 | VCP (0.41) | VCPHTR1AHTR7TP53BP1GSK3B | |
| SCHEMBL19365436 | 0.91 | VCP (0.41) | VCPHTR1AHTR7TP53BP1GSK3B | |
| SCHEMBL19365269 | 0.91 | KARS1 (0.45) | GSK3BDYRK1AKARS1DHFRJAK2 | |
| SCHEMBL19365745 | 0.91 | DHFR (0.38) | VCPHTR1AHTR7TP53BP1GSK3B | |
| SCHEMBL19365756 | 0.89 | VCP (0.38) | VCPHTR1AHTR7TP53BP1GSK3B | |
| SCHEMBL19365292 | 0.89 | VCP (0.40) | VCPHTR1AHTR7TP53BP1GSK3B | |
| SCHEMBL19365317 | 0.88 | GSK3B (0.39) | GSK3BDYRK1ACNR2TRPV1FAAH | |
| SCHEMBL19670365 | 0.88 | VCP (0.37) | VCPGSK3BDYRK1AGRM5JAK2 | |
| SCHEMBL19365613 | 0.88 | FAAH (0.40) | GSK3BDYRK1ADRD2CNR2TRPV1 | |
| SCHEMBL19670231 | 0.85 | USP30 (0.40) | GSK3BDYRK1AGRM5CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |