Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365517 | 0.88 | BRAF (0.40) | FGFR4KCNH2TNIKLRRK2PDK1 | |
| SCHEMBL19670584 | 0.87 | FAAH (0.41) | FAAHFGFR4KCNH2CYP3A4TSHR | |
| SCHEMBL19670231 | 0.85 | USP30 (0.40) | USP30KCNH2TNIKPDK1PDK2 | |
| SCHEMBL19670373 | 0.85 | KDR (0.41) | FAAHFGFR4MAPK1CSNK1DCSNK1E | |
| SCHEMBL17618456 | 0.85 | LRRK2 (0.41) | FAAHFGFR4USP30KCNH2TNIK | |
| SCHEMBL19670266 | 0.85 | FGFR4 (0.41) | FAAHFGFR4KCNH2TSHRMAPK1 | |
| SCHEMBL19365394 | 0.84 | FAAH (0.39) | FAAHFGFR4USP30KCNH2ALDH1A1 | |
| SCHEMBL19365299 | 0.84 | FGFR4 (0.40) | FAAHFGFR4KCNH2ALDH1A1MAPK1 | |
| SCHEMBL19365743 | 0.84 | THRB (0.40) | USP30KCNH2TNIKCYP1A2CYP3A4 | |
| SCHEMBL17618504 | 0.84 | LRRK2 (0.42) | FAAHFGFR4USP30ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |