Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 12/20 | 0.42 |
| ▸ | HTR2A | P28223 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | HTR2B | P41595 | 2/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670428 | 0.89 | ABL1 (0.40) | HTR2CABL1FAAHFYN | |
| SCHEMBL19670179 | 0.89 | HTR2C (0.46) | HTR2CHTR2ACYP1A2HTR2BABL1 | |
| SCHEMBL19670590 | 0.88 | IRAK4 (0.41) | ABL1FYN | |
| SCHEMBL19670385 | 0.86 | MPL (0.44) | FAAHFYN | |
| SCHEMBL19670386 | 0.85 | CACNA1H (0.37) | HTR2ACACNA1HFYN | |
| SCHEMBL19670164 | 0.85 | GSK3B (0.40) | — | |
| SCHEMBL19670388 | 0.84 | CACNA1G (0.46) | HTR2CHTR2AABL1CACNA1GCACNA1H | |
| SCHEMBL19670393 | 0.84 | ABL1 (0.42) | HTR2CHTR2AABL1CACNA1GCACNA1H | |
| SCHEMBL19670257 | 0.84 | HPGDS (0.38) | — | |
| SCHEMBL19670238 | 0.83 | TRPA1 (0.38) | ABL1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |