Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365749 | 0.87 | CA2 (0.42) | MEN1POLBKMT2ATRPV1 | |
| SCHEMBL19670249 | 0.85 | CA2 (0.42) | TRPV1 | |
| SCHEMBL16776362 | 0.84 | TRPV1 (0.51) | MEN1POLBKMT2ATRPV1JAK3 | |
| SCHEMBL17623988 | 0.82 | NPC1 (0.37) | MEN1KMT2ANPC1 | |
| SCHEMBL19670123 | 0.82 | TRPA1 (0.37) | — | |
| SCHEMBL19364921 | 0.81 | KIF18A (0.38) | MEN1KMT2ANPC1 | |
| SCHEMBL20633183 | 0.81 | JAK3 (0.45) | MEN1POLBKMT2ATRPV1JAK3 | |
| SCHEMBL19365694 | 0.81 | CHRM3 (0.45) | MEN1KMT2A | |
| SCHEMBL19365573 | 0.81 | CA2 (0.39) | — | |
| SCHEMBL19670366 | 0.79 | NAMPT (0.42) | POLBROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |