Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19699078 | 0.91 | NAMPT (0.42) | CA2CA9ELANEKDM4ELMNA | |
| SCHEMBL19670366 | 0.89 | NAMPT (0.42) | CA2CA9ELANECHRM4CHRM5 | |
| SCHEMBL19670249 | 0.89 | CA2 (0.42) | CA2CA9KDM4EALDH1A1KDM4C | |
| SCHEMBL19365749 | 0.88 | CA2 (0.42) | CA2CA9LMNACHRM4CHRM5 | |
| SCHEMBL19865035 | 0.87 | CA2 (0.37) | CA2CA9ELANELMNATRPV4 | |
| SCHEMBL17624670 | 0.82 | CA2 (0.39) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL19670123 | 0.82 | TRPA1 (0.37) | CA2CA9CHRM4CHRM5CHRM1 | |
| SCHEMBL19365407 | 0.81 | MEN1 (0.49) | — | |
| SCHEMBL19670572 | 0.81 | LMNA (0.35) | CA2CA9LMNAMAPTTP53 | |
| SCHEMBL19706277 | 0.80 | CA2 (0.39) | CA2CA9LMNACHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |