Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 15/20 | 0.41 |
| ▸ | RAF1 | P04049 | 14/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775898 | 0.84 | MEN1 (0.43) | MEN1KMT2ARXFP1BRAFRAF1 | |
| SCHEMBL19670135 | 0.83 | MEN1 (0.41) | MEN1KMT2ABRAFRAF1MAPT | |
| SCHEMBL19670629 | 0.83 | CA2 (0.40) | MEN1KMT2ABRAFRAF1MAPT | |
| SCHEMBL17618418 | 0.83 | MEN1 (0.44) | MEN1KMT2ARXFP1BRAFRAF1 | |
| SCHEMBL19670179 | 0.83 | HTR2C (0.46) | MEN1KMT2ABRAF | |
| SCHEMBL19670225 | 0.82 | MLLT1 (0.38) | MEN1KMT2ABRAFRAF1MAPT | |
| SCHEMBL19670214 | 0.82 | TRPA1 (0.38) | MEN1KMT2ABRAFRAF1MAPT | |
| SCHEMBL19670212 | 0.82 | RHOA (0.45) | MEN1KMT2ABRAFRAF1MAPT | |
| SCHEMBL19670644 | 0.81 | HSD17B10 (0.37) | MEN1KMT2ABRAFRAF1MAPT | |
| SCHEMBL19670425 | 0.81 | KMT2A (0.39) | MEN1KMT2ABRAFRAF1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |