Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLLT1 | Q03111 | 4/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 3/20 | 0.37 |
| ▸ | BRAF | P15056 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670386 | 0.90 | CACNA1H (0.37) | MLLT1RAF1BRAFCREBBPMCHR1 | |
| SCHEMBL19670253 | 0.87 | MLLT1 (0.38) | MLLT1CREBBPTRPV1MLLT3MAOB | |
| SCHEMBL19670251 | 0.87 | MLLT1 (0.39) | MLLT1MAPTCREBBPTRPV1MLLT3 | |
| SCHEMBL19670179 | 0.85 | HTR2C (0.46) | BRAFTRPV1CSF1RKITMEN1 | |
| SCHEMBL19670214 | 0.84 | TRPA1 (0.38) | RAF1BRAFMAPTCHRM4CHRM5 | |
| SCHEMBL19670135 | 0.84 | MEN1 (0.41) | RAF1BRAFMAPTTRPV1MCHR1 | |
| SCHEMBL19670629 | 0.83 | CA2 (0.40) | RAF1BRAFMAPTTRPV1CHRM4 | |
| SCHEMBL17618414 | 0.83 | MAPT (0.40) | DRD4DRD3SIGMAR1RAF1BRAF | |
| SCHEMBL19670644 | 0.83 | HSD17B10 (0.37) | RAF1BRAFMAPTTRPV1CHRM4 | |
| SCHEMBL16775894 | 0.83 | FYN (0.37) | MLLT1DRD4DRD3SIGMAR1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |