Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | UBE2M | P61081 | 1/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670135 | 0.92 | MEN1 (0.41) | CA2CA9TRPV1MEN1KMT2A | |
| SCHEMBL19670425 | 0.90 | KMT2A (0.39) | CA2CA9MEN1KMT2ALMNA | |
| SCHEMBL19670644 | 0.87 | HSD17B10 (0.37) | CA2CA9TRPV1MEN1KMT2A | |
| SCHEMBL19670179 | 0.87 | HTR2C (0.46) | TRPV1MEN1KMT2ATSHRUBE2M | |
| SCHEMBL19670214 | 0.85 | TRPA1 (0.38) | CA2CA9MEN1KMT2ALMNA | |
| SCHEMBL19670225 | 0.83 | MLLT1 (0.38) | CA2CA9TRPV1MEN1KMT2A | |
| SCHEMBL19670580 | 0.83 | TRPV1 (0.43) | CA2CA9TRPV1MEN1KMT2A | |
| SCHEMBL19670212 | 0.83 | RHOA (0.45) | CA2CA9TRPV1MEN1KMT2A | |
| SCHEMBL19670353 | 0.83 | MEN1 (0.44) | MEN1KMT2AMAPTBRAFRAF1 | |
| SCHEMBL19670209 | 0.83 | CNR2 (0.36) | CA2CA9MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |