Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670235 | 0.90 | GSK3B (0.36) | MAPTABL1MEN1KMT2A | |
| SCHEMBL17618655 | 0.86 | CCNC (0.39) | P2RX7CCNCCDK8MPLMAPT | |
| SCHEMBL19364899 | 0.85 | ALOX15 (0.38) | HTR2CCYP1A2HTR2BBRAFKDR | |
| SCHEMBL19365761 | 0.84 | MAPT (0.37) | MAPTMEN1KMT2A | |
| SCHEMBL19670491 | 0.84 | FAAH (0.38) | CDK8KMT2A | |
| SCHEMBL19365409 | 0.79 | RAB9A (0.41) | ABL1MEN1KMT2A | |
| SCHEMBL19365410 | 0.79 | RAB9A (0.41) | ABL1MEN1KMT2A | |
| SCHEMBL16776170 | 0.78 | FGFR4 (0.45) | HTR2CHTR2ACYP1A2HTR2B | |
| SCHEMBL19365401 | 0.78 | MALT1 (0.40) | — | |
| SCHEMBL19365400 | 0.78 | MALT1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |