Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | RHOA | P61586 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365619 | 0.89 | KMO (0.37) | KDREPHB4PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365541 | 0.83 | RHOA (0.35) | KDREPHB4PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19670403 | 0.81 | BRAF (0.39) | KDREPHB4PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19670289 | 0.76 | BRAF (0.42) | KDREPHB4PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19706034 | 0.75 | ALDH1A1 (0.39) | PIK3CDPIK3CAPIK3CGKMOCNR2 | |
| SCHEMBL19670382 | 0.74 | NPY5R (0.42) | KDREPHB4PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365806 | 0.73 | RHOA (0.42) | PIK3CDPIK3CAPIK3CGKMOBRAF | |
| SCHEMBL19670450 | 0.73 | MEN1 (0.41) | EPHB4PIK3CDPIK3CAPIK3CGKDM4E | |
| SCHEMBL19365786 | 0.72 | RHOA (0.37) | PIK3CDPIK3CAPIK3CGKMOBRAF | |
| SCHEMBL19670424 | 0.72 | MAPK14 (0.37) | EPHB4PIK3CDPIK3CAPIK3CGKMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |