Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY1 | Q08828 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365413 | 0.92 | ADCY1 (0.50) | ADCY1KDM4ELMNATDP1L3MBTL1 | |
| SCHEMBL19670556 | 0.88 | ADCY1 (0.43) | ADCY1KDM4ELMNATDP1L3MBTL1 | |
| SCHEMBL17618854 | 0.87 | ADCY1 (0.40) | ADCY1KDM4ELMNATDP1L3MBTL1 | |
| SCHEMBL19670497 | 0.81 | MAPT (0.45) | KDM4ELMNAL3MBTL1GAASMN1; SMN2 | |
| SCHEMBL19670189 | 0.79 | ADCY1 (0.50) | ADCY1KDM4ELMNAL3MBTL1ADCY8 | |
| SCHEMBL16776408 | 0.79 | KDM4E (0.42) | ADCY1KDM4ELMNATDP1L3MBTL1 | |
| SCHEMBL19670299 | 0.78 | FYN (0.43) | KDM4ELMNAGAASMN1; SMN2HTT | |
| SCHEMBL19670573 | 0.78 | MAPK10 (0.39) | KDM4ELMNAPOLBGAASMN1; SMN2 | |
| SCHEMBL16250000 | 0.78 | ADCY1 (0.49) | ADCY1KDM4ELMNAL3MBTL1ADCY8 | |
| SCHEMBL19670476 | 0.76 | TRPV1 (0.46) | MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |