Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 7/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 7/20 | 0.36 |
| ▸ | ITGAL | P20701 | 7/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365721 | 0.93 | FGFR4 (0.37) | ITGB2ICAM1ITGALFGFR4FAAH | |
| SCHEMBL19365725 | 0.93 | FGFR4 (0.37) | ITGB2ICAM1ITGALFGFR4FAAH | |
| SCHEMBL19365442 | 0.89 | FAAH (0.37) | FGFR4SLC34A1FAAHMAP3K12SYK | |
| SCHEMBL19361175 | 0.89 | ITGB2 (0.38) | ITGB2ICAM1ITGALFGFR4SLC34A1 | |
| SCHEMBL19670623 | 0.88 | KARS1 (0.38) | ITGB2ICAM1ITGALKARS1MAP3K12 | |
| SCHEMBL19670149 | 0.86 | FGFR4 (0.39) | FGFR4FAAHHPGDSPDK1PDK2 | |
| SCHEMBL19670334 | 0.86 | FGFR4 (0.36) | FGFR4FAAHHPGDSMAP3K12PDK1 | |
| SCHEMBL19670490 | 0.86 | SLC34A1 (0.36) | ITGB2ICAM1ITGALSLC34A1FAAH | |
| SCHEMBL19365299 | 0.85 | FGFR4 (0.40) | FGFR4FAAHHPGDSSYKPDK1 | |
| SCHEMBL19670631 | 0.85 | FAAH (0.35) | ITGB2ICAM1ITGALFGFR4FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |