Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | PIM1 | P11309 | 3/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706215 | 0.90 | MAP4K4 (0.34) | USP30JAK3 | |
| SCHEMBL19706928 | 0.86 | HRH3 (0.33) | MAPK1USP30HRH3 | |
| SCHEMBL19670481 | 0.83 | KARS1 (0.41) | MAPK1HRH3 | |
| SCHEMBL19670625 | 0.83 | HRH3 (0.33) | MAPK1USP30HRH3 | |
| SCHEMBL19670633 | 0.82 | WNT3A (0.34) | MAPK1PIM1HRH3 | |
| SCHEMBL16754289 | 0.82 | MAPK1 (0.34) | MAPK1USP30CCNE1CDK2JAK3 | |
| SCHEMBL19670538 | 0.81 | ROCK1 (0.34) | MAPK1USP30JAK3HRH3 | |
| SCHEMBL19706212 | 0.80 | HRH3 (0.34) | MAPK1PIM1JAK3HRH3 | |
| SCHEMBL19706138 | 0.80 | WNT3A (0.33) | MAPK1JAK3HRH3 | |
| SCHEMBL19670355 | 0.76 | PIM1 (0.37) | MAPK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |