Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 3/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670504 | 0.86 | MAPK1 (0.32) | HRH3MAPK1USP30 | |
| SCHEMBL19670481 | 0.85 | KARS1 (0.41) | HRH3MAPK1 | |
| SCHEMBL19670625 | 0.85 | HRH3 (0.33) | HRH3SCDMAPK1MAP4K4USP30 | |
| SCHEMBL19670538 | 0.85 | ROCK1 (0.34) | HRH3MAPK1WNT3AMAP4K4USP30 | |
| SCHEMBL19670633 | 0.84 | WNT3A (0.34) | HRH3SCDMAPK1WNT3AMAP4K4 | |
| SCHEMBL19706215 | 0.84 | MAP4K4 (0.34) | MAP4K4USP30 | |
| SCHEMBL19706212 | 0.82 | HRH3 (0.34) | HRH3MAPK1MAP4K4 | |
| SCHEMBL19706138 | 0.82 | WNT3A (0.33) | HRH3MAPK1WNT3A | |
| SCHEMBL16754455 | 0.81 | USP30 (0.36) | SCDMAPK1WNT3AUSP30IRAK4 | |
| SCHEMBL17778208 | 0.81 | USP30 (0.36) | SCDMAPK1WNT3AUSP30IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355705-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | HRH3 3142/4885SCD 1161/4885MAPK1 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.