Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.30 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.30 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23889696 | 1.00 | KDM1A (0.32) | KDM1ARCOR1TPSAB1TPSD1TPSG1 | |
| SCHEMBL22220080 | 0.85 | — | — | |
| SCHEMBL19683904 | 0.83 | FAP (0.33) | KDM1ARCOR1 | |
| SCHEMBL23020008 | 0.80 | OPRM1 (0.35) | KDM1ARCOR1TPSAB1TPSD1TPSG1 | |
| SCHEMBL20830999 | 0.76 | OPRM1 (0.36) | — | |
| SCHEMBL19683911 | 0.76 | OPRM1 (0.36) | — | |
| SCHEMBL17807576 | 0.73 | HTR2A (0.41) | — | |
| SCHEMBL19684096 | 0.69 | MEN1 (0.33) | — | |
| SCHEMBL23889723 | 0.68 | PSEN1 (0.34) | KDM1ARCOR1 | |
| SCHEMBL19698830 | 0.68 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648315-B2 | Silvestrol antibody-drug conjugates and methods of use | GENENTECH, INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20200222545-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2020-07-16 | — | — | US | disclosed |
| US-10639378-B2 | Silvestrol antibody-drug conjugates and methods of use | GENENTECH, INC. (US) | 2020-05-05 | — | — | US | disclosed |
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | SHBG, EPCAM, ITGAV | KDM1A 703/4885RCOR1 4152/4885TPSAB1 418/4885 |
| US-20200222545-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | SHBG, EPCAM, ITGAV | KDM1A 703/4885RCOR1 4152/4885TPSAB1 418/4885 |
| US-11648315-B2 | Silvestrol antibody-drug conjugates and methods of use | SHBG, EPCAM, ITGAV | KDM1A 703/4885RCOR1 4152/4885TPSAB1 418/4885 |
| US-10639378-B2 | Silvestrol antibody-drug conjugates and methods of use | SHBG, EPCAM, ITGAV | KDM1A 703/4885RCOR1 4152/4885TPSAB1 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.