Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | FPR3 | P25089 | 1/20 | 0.30 |
| ▸ | FPR2 | P25090 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19698830 | 0.93 | ALDH1A1 (0.33) | MEN1KMT2AALDH1A1PSEN1PSEN2 | |
| SCHEMBL21949515 | 0.91 | MEN1 (0.34) | MEN1KMT2AALDH1A1PSEN1PSEN2 | |
| SCHEMBL23889723 | 0.88 | PSEN1 (0.34) | MEN1KMT2AALDH1A1PSEN1PSEN2 | |
| SCHEMBL19683917 | 0.85 | SMN1; SMN2 (0.36) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL19684092 | 0.84 | MEN1 (0.34) | MEN1KMT2AALDH1A1PSEN1PSEN2 | |
| SCHEMBL23889705 | 0.83 | RAB9A (0.34) | MEN1KMT2AALDH1A1PSEN1PSEN2 | |
| SCHEMBL22219876 | 0.79 | HTR1A (0.36) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL19698817 | 0.77 | PKM (0.36) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL19684093 | 0.76 | SMN1; SMN2 (0.40) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL23020008 | 0.76 | OPRM1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170348422-A1 | SILVESTROL ANTIBODY-DRUG CONJUGATES AND METHODS OF USE | SHBG, EPCAM, ITGAV | MEN1 3118/4885KMT2A 503/4885ALDH1A1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.