SCHEMBL19685853

SCHEMBL19685853

Cc1coc(=O)c2ccc(-n3c4ccc(-c5ccccc5)cc4c4cc(-c5ccccc5)ccc43)cc12

nearest known ligand 0.37

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TNKS2 Q9H2K2 1/20 0.37
BRD4 O60885 1/20 0.36
KCNA3 P22001 3/20 0.35
CTRC Q99895 1/20 0.35
PTPN1 P18031 3/20 0.34
PTPN2 P17706 2/20 0.34
MAOB P27338 1/20 0.34
TSPO P30536 1/20 0.33
NR4A2 P43354 2/20 0.33
TOP2A P11388 1/20 0.32
EDNRB P24530 1/20 0.32
EDNRA P25101 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19685850 0.87 KDM4E (0.38) EDNRBEDNRA
SCHEMBL19685851 0.82 APP (0.35)
SCHEMBL19685804 0.82 KDM4E (0.38) EDNRBEDNRA
SCHEMBL19685895 0.82 PTPN1 (0.47) TNKS2PTPN1PTPN2MAOBTOP2A
SCHEMBL19685689 0.82 PTPN1 (0.50) PTPN1PTPN2MAOBTOP2A
SCHEMBL19685802 0.79 PGR (0.38) CTRCPTPN1PTPN2TSPONR4A2
SCHEMBL19685731 0.78 BRD4 (0.52) TNKS2BRD4MAOBNR4A2
SCHEMBL19686345 0.77 ESRRA (0.43) TNKS2BRD4MAOBNR4A2
SCHEMBL19686027 0.76 BRD4 (0.49) TNKS2BRD4MAOBTSPONR4A2
SCHEMBL19686113 0.76 TNKS2 (0.38) TNKS2BRD4KCNA3PTPN1PTPN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10714693-B2 Polycyclic compound and organic electroluminescence device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2020-07-14 US disclosed
US-20170352817-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2017-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10714693-B2 Polycyclic compound and organic electroluminescence device including the same CYC1, CCNA1, CYCS TNKS2 3059/4885BRD4 740/4885KCNA3 677/4885
US-20170352817-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME CYC1, CCNA1, CYCS TNKS2 3059/4885BRD4 740/4885KCNA3 677/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.