SCHEMBL19686259

SCHEMBL19686259

O=C1OCCc2cc(-n3c4ccc(-c5ccccc5)cc4c4cc(-c5ccccc5)ccc43)ccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.40
ALDH1A1 P00352 2/20 0.40
PARP10 Q53GL7 1/20 0.40
PARP11 Q9NR21 1/20 0.40
MAPT P10636 2/20 0.38
RECQL P46063 1/20 0.38
PDGFRB P09619 1/20 0.38
SRC P12931 1/20 0.38
KDR P35968 1/20 0.38
EDNRB P24530 1/20 0.37
EDNRA P25101 1/20 0.37
HRH3 Q9Y5N1 1/20 0.36
TDP2 O95551 1/20 0.35
PRKDC P78527 3/20 0.34
AR P10275 2/20 0.34
HTT P42858 2/20 0.34
MEN1 O00255 1/20 0.34
APAF1 O14727 1/20 0.34
NPC1 O15118 1/20 0.34
THRB P10828 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19685811 0.90 EDNRB (0.37) LMNAALDH1A1PARP10PARP11MAPT
SCHEMBL19685744 0.87 LMNA (0.55) LMNAALDH1A1MAPTRECQLPRF1
SCHEMBL19686073 0.86 LMNA (0.46) LMNAALDH1A1MAPTRECQLEDNRB
SCHEMBL15613804 0.85 PARP10 (0.40) LMNAPARP10PARP11MAPTEDNRB
SCHEMBL19685907 0.82 HSD17B1 (0.50) LMNAALDH1A1PARP10PARP11MAPT
SCHEMBL15557386 0.82 PARP10 (0.55) LMNAALDH1A1PARP10PARP11MAPT
SCHEMBL19686258 0.82 ALDH1A1 (0.38) LMNAALDH1A1MAPTRECQLEDNRB
SCHEMBL15613806 0.82 KDM4E (0.42) LMNAALDH1A1PARP10PARP11EDNRB
SCHEMBL19685759 0.80 MAOB (0.43) LMNAALDH1A1MAPTRECQLEDNRB
SCHEMBL17209244 0.79 TDP2 (0.43) PARP10PARP11EDNRBEDNRAHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10714693-B2 Polycyclic compound and organic electroluminescence device including the same SAMSUNG DISPLAY CO., LTD. (KR) 2020-07-14 US disclosed
US-20170352817-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION (JP) 2017-12-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10714693-B2 Polycyclic compound and organic electroluminescence device including the same CYC1, CCNA1, CYCS LMNA 3026/4885ALDH1A1 572/4885PARP10 795/4885
US-20170352817-A1 POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME CYC1, CCNA1, CYCS LMNA 3026/4885ALDH1A1 572/4885PARP10 795/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.