Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7953567 | 0.97 | CALM1 (0.63) | CALM1SIGMAR1TSHRMEN1CYP3A4 | |
| Bromide SCHEMBL7949095 | 0.97 | CALM1 (0.63) | CALM1SIGMAR1TSHRMEN1CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL18010564 | 0.97 | CALM1 (0.63) | CALM1SIGMAR1TSHRMEN1CYP3A4 | |
| Methylamine SCHEMBL27607291 | 0.91 | CALM1 (0.55) | CALM1SIGMAR1TSHRMEN1CYP3A4 | |
| SCHEMBL1106684 | 0.88 | IDO1 (0.58) | CALM1TSHRMEN1CYP3A4KMT2A | |
| SCHEMBL8752833 | 0.87 | CYP1A2 (0.71) | CALM1SIGMAR1TSHRCYP1A2L3MBTL1 | |
| SCHEMBL8094422 | 0.85 | CALM1 (0.92) | CALM1TSHRCYP3A4LTA4HIDH1 | |
| SCHEMBL972712 | 0.85 | CALM1 (0.92) | CALM1TSHRCYP3A4LTA4HIDH1 | |
| SCHEMBL8196751 | 0.83 | SIGMAR1 (0.58) | SIGMAR1TSHRMEN1HPGDALOX15 | |
| SCHEMBL585374 | 0.83 | L3MBTL1 (0.59) | CYP3A4CYP1A2L3MBTL1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 407 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118198570-B | High-magnification regenerated graphite anode material and preparation method and application thereof | 深圳鑫茂新能源技术股份有限公司 | 2024-07-16 | — | — | CN | claimed |
| CN-118198570-A | High-magnification regenerated graphite anode material and preparation method and application thereof | 深圳鑫茂新能源技术股份有限公司 | 2024-06-14 | — | — | CN | claimed |
| CN-117658567-A | Early-strength and quick-hardening conductive concrete and preparation method thereof | 深圳市政集团有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-113443950-B | Method for reducing carbonyl into methylene under illumination | 中山大学 | 2023-11-03 | — | — | CN | claimed |
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | ABBVIE INC. (US) | 2020-02-11 | — | — | US | claimed |
| CN-106565517-B | A method of amide is prepared by arylmethane derivative and nitrile | 湖南大学 | 2018-08-17 | — | — | CN | claimed |
| EP-3350187-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | AbbVie Inc. (US) | 2018-07-25 | — | — | EP | claimed |
| CN-104140379-B | Fluorine-containing extractant and application thereof | 中国科学院上海有机化学研究所 | 2017-05-10 | — | — | CN | claimed |
| CN-106565517-A | Method for preparing amide from aryl methane derivative and nitrile | 湖南大学 | 2017-04-19 | — | — | CN | claimed |
| WO-2017046117-A1 | SUBSTITUTED ISOXAZOLOPYRIDAZINONES AND ISOTHIAZOLOPYRIDAZINONES AND METHODS OF USE | ABBVIE INC. (US) | 2017-03-23 | — | — | WO | claimed |
| US-5147876-A | Nervous system disorders | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1992-09-15 | — | — | US | claimed |
| US-5126340-A | Antidepressants | AMERICAN CYANAMID COMPANY (US) | 1992-06-30 | — | — | US | claimed |
| EP-0421823-A2 | Novel tetracyclic compounds having anti-allergic and anti-asthmatic activities, their preparation and use | Sankyo Company Limited (JP) | 1991-04-10 | — | — | EP | claimed |
| EP-0415030-A2 | 1-Substituted-1,2-dihydro-4-[(substituted)-phenyl]imidazo-[1,5-A]pyrimidine-8-carbonitriles | AMERICAN CYANAMID COMPANY (US) | 1991-03-06 | — | — | EP | claimed |
| US-4963552-A | HYPOTENSIVE AGENTS, ANTIDEPRESSANTS | AMERICAN CYANAMID COMPANY (US) | 1990-10-16 | — | — | US | claimed |
| EP-0379806-A2 | Pyrimidines and their pharmaceutical acceptable salts, and their use as medicines | MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) | 1990-08-01 | — | — | EP | claimed |
| US-4927829-A | Heterocyclic compounds and antiulcer agents | SHIONOGI & CO., LTD. (JP) | 1990-05-22 | — | — | US | claimed |
| EP-0264773-A1 | 4,5-dihydro and 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidines | AMERICAN CYANAMID COMPANY (US) | 1988-04-27 | — | — | EP | claimed |
| EP-0001644-A1 | N-substituted mercaptoacetamidines and pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1979-05-02 | — | — | EP | claimed |
| US-4144271-A | IMMUNOREGULANTS | MERCK & CO., INC. (US) | 1979-03-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10556914-B2 | Substituted isoxazolopyridazinones and isothiazolopyridazinones and methods of use | GABRB1, GABBR1, GABBR2 | CALM1 613/4885SIGMAR1 316/4885TSHR 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.