Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNPH1 | O43598 | 1/20 | 0.46 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.45 |
| ▸ | SLC28A2 | O43868 | 2/20 | 0.42 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19699217 | 0.87 | TRPM2 (0.58) | DNPH1TRPM2SLC28A2HSPA8SIRT2 | |
| SCHEMBL19699207 | 0.86 | DNPH1 (0.58) | DNPH1SLC28A2HSPA8NT5ESIRT2 | |
| SCHEMBL19699229 | 0.81 | POLB (0.56) | DNPH1NT5EPOLBIMPDH2 | |
| SCHEMBL19699224 | 0.80 | DNPH1 (0.51) | DNPH1TRPM2SLC28A2HSPA8NT5E | |
| SCHEMBL19699208 | 0.77 | SIRT2 (0.49) | DNPH1SLC28A2HSPA8NT5ESIRT2 | |
| SCHEMBL19699209 | 0.75 | DNPH1 (0.74) | DNPH1NT5EPOLBP2RX3P2RX2 | |
| SCHEMBL8979282 | 0.74 | TRPM2 (0.61) | TRPM2SIRT2SIRT1POLBTYMS | |
| SCHEMBL17363546 | 0.73 | SIRT2 (0.58) | DNPH1TRPM2SIRT2SIRT1IMPDH2 | |
| SCHEMBL17363547 | 0.73 | SIRT2 (0.58) | DNPH1TRPM2SIRT2SIRT1IMPDH2 | |
| SCHEMBL16871847 | 0.73 | SIRT2 (0.58) | DNPH1TRPM2SIRT2SIRT1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10342819-B2 | Oligonucleotide having non-natural nucleotide at 5′-terminal thereof | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2019-07-09 | — | — | US | disclosed |
| US-20170354673-A1 | OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-12-14 | — | — | US | disclosed |
| US-20170354673-A1 | OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10342819-B2 | Oligonucleotide having non-natural nucleotide at 5′-terminal thereof | RNGTT, UPF1, NSUN3 | DNPH1 2051/4885TRPM2 4847/4885SLC28A2 305/4885 |
| US-20170354673-A1 | OLIGONUCLEOTIDE HAVING NON-NATURAL NUCLEOTIDE AT 5'-TERMINAL THEREOF | RNGTT, UPF1, NSUN3 | DNPH1 2035/4885TRPM2 4843/4885SLC28A2 314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.