Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.60 |
| ▸ | CASP2 | P42575 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17740185 | 0.87 | FAAH (0.43) | FAAHL3MBTL1LMNASMN1; SMN2EPHX1 | |
| SCHEMBL19704263 | 0.85 | FAAH (0.54) | FAAHCASP2L3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL19703926 | 0.83 | CASP2 (0.56) | FAAHCASP2L3MBTL1NAAAEPHX1 | |
| SCHEMBL19703929 | 0.82 | CASP2 (0.54) | FAAHCASP2L3MBTL1NAAA | |
| SCHEMBL19703927 | 0.82 | CASP2 (0.54) | FAAHCASP2L3MBTL1NAAA | |
| SCHEMBL19703928 | 0.81 | CASP2 (0.57) | FAAHCASP2L3MBTL1NAAA | |
| SCHEMBL6980315 | 0.80 | LMNA (0.41) | FAAHL3MBTL1LMNASMN1; SMN2MEN1 | |
| SCHEMBL13934654 | 0.80 | LMNA (0.47) | FAAHL3MBTL1LMNASMN1; SMN2 | |
| SCHEMBL13857031 | 0.77 | FAAH (0.67) | FAAHCASP2NAAAEPHX1MEN1 | |
| SCHEMBL27986572 | 0.76 | FAAH (0.70) | FAAHCASP2NAAAEPHX1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355731-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | NOVARTIS INSTITUTE FOR FUNCTIONAL GENOMICS, INC., DBA GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION | 2017-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355731-A1 | AMATOXIN DERIVATIVES AND CONJUGATES THEREOF AS INHIBITORS OF RNA POLYMERASE | RNGTT, RNASE1, RNMT | FAAH 3895/4885CASP2 2689/4885L3MBTL1 1981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.