Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 4/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1359862 | 0.78 | MCL1 (0.39) | IMPDH2MCL1BRD4KDM4EALDH1A1 | |
| SCHEMBL1971648 | 0.77 | KDM4E (0.46) | BRD4KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL27823720 | 0.71 | PRMT5 (0.40) | KDM4EALDH1A1CYP1A2HPGDPRMT5 | |
| SCHEMBL28404022 | 0.71 | XDH (0.68) | XDH | |
| SCHEMBL15536272 | 0.68 | MCL1 (0.52) | MCL1 | |
| SCHEMBL7293153 | 0.68 | IMPDH2 (0.61) | IMPDH2XDH | |
| SCHEMBL15334010 | 0.68 | TRPA1 (0.56) | BRD4KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL14745636 | 0.67 | XDH (0.40) | XDHKDM4E | |
| SCHEMBL22450677 | 0.67 | IMPDH2 (0.59) | IMPDH2XDHKDM4EALDH1A1 | |
| SCHEMBL13385265 | 0.67 | IMPDH2 (0.59) | IMPDH2XDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334662-A1 | PYRINE OR PYRAZINE DERIVATIVES FOR TREATING HCV | F. Hoffmann-La Roche AG (CH) | 2011-06-22 | — | — | EP | claimed |
| WO-2010034671-A1 | PYRINE OR PYRAZINE DERIVATIVES FOR TREATING HCV | F. HOFFMANN-LA ROCHE AG (CH) | 2010-04-01 | — | — | WO | claimed |