Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201979 | 0.83 | MAPK1 (0.56) | ALDH1A1CYP1A2RAB9ALMNAHSD17B10 | |
| SCHEMBL28742452 | 0.83 | ALDH1A1 (0.61) | ALDH1A1CYP1A2RAB9ASIRT2SIRT3 | |
| SCHEMBL1025076 | 0.82 | SIRT2 (0.48) | SIRT2 | |
| SCHEMBL16230241 | 0.81 | APP (0.41) | ALDH1A1RAB9ASIRT2SIRT3HSD17B10 | |
| SCHEMBL791661 | 0.81 | ALDH1A1 (0.59) | ALDH1A1CYP1A2RAB9ASIRT2SIRT3 | |
| SCHEMBL26964 | 0.80 | NR3C1 (0.55) | ALDH1A1CYP1A2RAB9ALMNAPOLB | |
| SCHEMBL9815416 | 0.80 | RAB9A (0.63) | ALDH1A1CYP1A2RAB9ASIRT2SIRT3 | |
| SCHEMBL8063113 | 0.79 | CA2 (0.45) | ALDH1A1CYP1A2LMNATSHRCYP19A1 | |
| SCHEMBL12136904 | 0.78 | NFATC1 (0.58) | ALDH1A1CYP1A2RAB9ANPSR1POLB | |
| SCHEMBL7666457 | 0.76 | ALDH1A1 (0.59) | ALDH1A1CYP1A2RAB9ANPSR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110433162-A | It can be used as the dihydronaphthridine and related compound of the kinase inhibitor for treating proliferative disease | DECIPHERA PHARMACEUTICALS LLC | 2019-11-12 | — | — | CN | disclosed |
| CN-110403938-A | It can be used as the dihydronaphthridine and related compound of the kinase inhibitor for treating proliferative disease | DECIPHERA PHARMACEUTICALS LLC | 2019-11-05 | — | — | CN | disclosed |
| CN-104902895-B | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases | 德西费拉制药有限责任公司 | 2019-03-29 | — | — | CN | disclosed |
| EP-2858646-B1 | DIHYDRONAPHTHYRIDINES AND RELATED COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF PROLIFERATIVE DISEASES | DECIPHERA PHARMACEUTICALS LLC (US) | 2017-12-20 | — | — | EP | disclosed |