Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | IGF1R | P08069 | 1/20 | 0.55 |
| ▸ | GHSR | Q92847 | 7/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494751 | 0.96 | ATM (0.57) | ATMINSRIGF1RGHSRMRGPRX4 | |
| SCHEMBL17813135 | 0.85 | CA2 (0.68) | INSRIGF1RCYP1A2CA12CA1 | |
| SCHEMBL2857028 | 0.83 | INSR (0.49) | ATMINSRIGF1RMRGPRX4ALDH1A1 | |
| SCHEMBL21036095 | 0.80 | HTT (0.62) | INSRIGF1RMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL6529022 | 0.79 | GHSR (0.45) | GHSRALDH1A1CA12CA1CA2 | |
| SCHEMBL20036943 | 0.79 | INSR (0.75) | INSRIGF1RMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL1542592 | 0.79 | MRGPRX4 (0.67) | INSRIGF1RMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL5575066 | 0.78 | SNCA (0.63) | INSRIGF1RMRGPRX4ALDH1A1CYP1A2 | |
| SCHEMBL30437396 | 0.77 | NPC1 (0.65) | INSRIGF1RALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL758323 | 0.77 | ATM (0.66) | ATMCA1CA2CA9L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362221-A1 | INHIBITORS OF KIDNEY-TYPE GLUTAMINASE, GLS-1 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362221-A1 | INHIBITORS OF KIDNEY-TYPE GLUTAMINASE, GLS-1 | GLS, GLS2, GLUL | ATM 4173/4885INSR 1301/4885IGF1R 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.