Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | CTSK | P43235 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MGAM | O43451 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SI | P14410 | 2/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | STAT3 | P40763 | 1/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL148211 | 0.86 | MAPT (0.68) | GPR84KMT2AMEN1MAPTPKM | |
| SCHEMBL4099306 | 0.85 | HTR2A (0.54) | GPR84KMT2AMEN1MAPTPKM | |
| SCHEMBL24723275 | 0.82 | GPR84 (0.56) | GPR84KMT2AMEN1MAPTPKM | |
| SCHEMBL29003653 | 0.81 | NR4A2 (0.46) | GPR84KMT2AMEN1MAPTPKM | |
| SCHEMBL28034597 | 0.81 | GPR84 (0.55) | GPR84KMT2AMEN1MAPTPKM | |
| SCHEMBL29003655 | 0.81 | RAB9A (0.49) | MAPTHTR2AALDH1A1GAAKDM4E | |
| SCHEMBL29003630 | 0.80 | TDO2 (0.44) | GPR84HTR2AHTR2CMPO | |
| SCHEMBL9235264 | 0.80 | GABRA1 (0.47) | GPR84KMT2AMEN1HTR2AHIF1A | |
| SCHEMBL28783934 | 0.80 | GPR84 (0.54) | GPR84KMT2AMEN1MAPTPKM | |
| SCHEMBL7890292 | 0.80 | NR4A2 (0.47) | GPR84KMT2AMEN1HTR2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101522616-A | Indole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2009-09-02 | — | — | CN | claimed |
| CN-1181050-C | Novel substituted dimeric compounds, its preparing process and medicinal compsns. containing same | ɪά��ʵ���� | 2004-12-22 | — | — | CN | claimed |
| CN-1273967-A | Novel substituted dimeric compounds, its preparing process and medicinal compsns. containing same | ADIR (FR) | 2000-11-22 | — | — | CN | claimed |
| CN-113943244-B | Sulfur-containing gamma, gamma-diindolylbutyramide compounds prepared by difunctional reactions | 温州大学 | 2023-05-23 | — | — | CN | disclosed |
| CN-105916840-B | Benzazolyl compounds | 安斯泰来制药株式会社 | 2019-01-08 | — | — | CN | disclosed |
| US-9206156-B2 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2015-12-08 | — | — | US | disclosed |
| US-20130116283-A1 | Substituted indole derivatives | Grünenthal GmbH (DE) | 2013-05-09 | — | — | US | disclosed |
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-09-01 | — | — | US | disclosed |
| EP-2334643-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | Actelion Pharmaceuticals Ltd. (CH) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010044054-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-04-22 | — | — | WO | disclosed |
| CN-101522616-A | Indole derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2009-09-02 | — | — | CN | disclosed |
| US-20090215828-A1 | Substituted indole derivatives | GRUNENTHAL GMBH (DE) | 2009-08-27 | — | — | US | disclosed |
| CN-1181050-C | Novel substituted dimeric compounds, its preparing process and medicinal compsns. containing same | ɪά��ʵ���� | 2004-12-22 | — | — | CN | disclosed |
| CN-1128142-C | Novel substituted dipolymer compounds, prepn. method therefor, pharmaceutical compositions contg. same | ADIR (FR) | 2003-11-19 | — | — | CN | disclosed |
| CN-1277962-A | Novel substituted dipolymer compounds, prepn. method therefor, pharmaceutical compositions contg. same | ADIR (FR) | 2000-12-27 | — | — | CN | disclosed |
| CN-1273967-A | Novel substituted dimeric compounds, its preparing process and medicinal compsns. containing same | ADIR (FR) | 2000-11-22 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215828-A1 | Substituted indole derivatives | IDO1, IDO2, TPH1 | GPR84 1994/4885KMT2A 2203/4885MEN1 3427/4885 |
| US-20130116283-A1 | Substituted indole derivatives | IDO1, IDO2, TPH1 | GPR84 1994/4885KMT2A 2203/4885MEN1 3427/4885 |
| US-20110212968-A1 | PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES | HCRTR2, HCRTR1, HRH3 | GPR84 73/4885KMT2A 253/4885MEN1 525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.