Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | GUSB | P08236 | 3/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29003655 | 0.85 | RAB9A (0.49) | NR4A2MTNR1AMTNR1BHTR2A | |
| SCHEMBL2405000 | 0.84 | MPO (0.51) | MTNR1AMTNR1BGPR84HTR2ATRPM8 | |
| SCHEMBL11893370 | 0.82 | NR4A2 (0.50) | GABRA1GABRB1GABRA3GABRB2NR4A2 | |
| SCHEMBL29003613 | 0.82 | HTR2B (0.59) | NR4A2MTNR1AMTNR1BGPR84HTR2A | |
| SCHEMBL1972827 | 0.80 | GPR84 (0.59) | GPR84HTR2AHIF1AMEN1KMT2A | |
| SCHEMBL6835417 | 0.77 | MEN1 (0.51) | GABRA1GABRB1GABRA3GABRB2NR4A2 | |
| SCHEMBL29003653 | 0.77 | NR4A2 (0.46) | NR4A2GPR84HTR2AMEN1KMT2A | |
| SCHEMBL5217649 | 0.76 | GUSB (0.45) | GABRA1GABRB1GABRA3GABRB2NR4A2 | |
| SCHEMBL29003630 | 0.76 | TDO2 (0.44) | GPR84HTR2A | |
| SCHEMBL7890292 | 0.76 | NR4A2 (0.47) | NR4A2GUSBGPR84HTR2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8742100-B2 | Small molecule inhibitors of isoprenylcysteine carboxyl methyltransferase with potential anticancer activity | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2014-06-03 | — | — | US | disclosed |
| US-20120197014-A1 | SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE WITH POTENTIAL ANTICANCER ACTIVITY | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2012-08-02 | — | — | US | disclosed |
| EP-2459533-A1 | SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE WITH POTENTIAL ANTICANCER ACTIVITY | National University of Singapore (SG) | 2012-06-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120197014-A1 | SMALL MOLECULE INHIBITORS OF ISOPRENYLCYSTEINE CARBOXYL METHYLTRANSFERASE WITH POTENTIAL ANTICANCER ACTIVITY | ICMT, BHMT, SHMT1 | GABRA1 4364/4885GABRB1 4224/4885GABRA3 4349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.