Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.51 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.50 |
| ▸ | NNMT | P40261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7093993 | 0.84 | PTK2 (0.62) | PTK2CYP1A2GAAHCAR3NNMT | |
| SCHEMBL18715411 | 0.84 | HCAR3 (0.70) | BAZ2BHCAR3NNMTGRM5SMN1; SMN2 | |
| SCHEMBL82675 | 0.82 | HCAR3 (0.68) | PTK2CYP1A2GAAHCAR3KMT2A | |
| SCHEMBL19728674 | 0.82 | ALDH1A1 (0.56) | BAZ2BHCAR3NNMTGRM5ALDH1A1 | |
| SCHEMBL19151204 | 0.82 | SMN1; SMN2 (0.55) | BAZ2BHCAR3SMN1; SMN2TP53TSHR | |
| SCHEMBL25190504 | 0.81 | PTK2 (0.59) | PTK2CYP1A2GAAHCAR3NNMT | |
| SCHEMBL3465475 | 0.81 | NNMT (0.69) | PTK2CYP1A2GAAHCAR3NNMT | |
| SCHEMBL2487358 | 0.81 | NNMT (0.54) | BAZ2BHCAR3NNMTGRM5SMN1; SMN2 | |
| SCHEMBL29424855 | 0.81 | NNMT (0.54) | BAZ2BHCAR3NNMTGRM5SMN1; SMN2 | |
| SCHEMBL1854705 | 0.79 | MAPK1 (0.59) | PTK2CYP1A2GAAHCAR3NNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170362234-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170362234-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | PTK2 4052/4885CYP1A2 2481/4885GAA 1087/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.