Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | ERN1 | O75460 | 3/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19737558 | 0.79 | RAB9A (0.42) | NPC1KMT2AMAPTMEN1RXFP1 | |
| SCHEMBL22589190 | 0.73 | PARP1 (0.48) | LIMK1HSP90AA1NPC1KMT2AMAPT | |
| SCHEMBL19737563 | 0.72 | TTK (0.49) | HSP90AA1HSP90AB1PTK2NPC1KMT2A | |
| SCHEMBL28623786 | 0.72 | NPC1 (0.52) | HSP90AA1HSP90AB1PTK2NPC1ERN1 | |
| SCHEMBL21088649 | 0.72 | MEN1 (0.46) | LIMK1NPC1KMT2AMAPTMEN1 | |
| SCHEMBL28362190 | 0.71 | ERN1 (0.47) | HSP90AA1HSP90AB1PTK2NPC1ERN1 | |
| SCHEMBL19737710 | 0.71 | GBA1 (0.41) | LIMK1NPC1KMT2AMAPTMEN1 | |
| SCHEMBL14012886 | 0.70 | ERN1 (0.51) | ERN1KDM4ECYP2A6CYP3A4CYP2C9 | |
| SCHEMBL14884092 | 0.70 | NPC1 (0.59) | LIMK1HSP90AA1HSP90AB1PTK2NPC1 | |
| SCHEMBL2456594 | 0.70 | KMT2A (0.63) | HSP90AA1HSP90AB1NPC1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | THE UNIVERSITY OF TOKYO (JP) | 2020-06-23 | — | — | US | disclosed |
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | THE UNIVERSITY OF TOKYO (JP) | 2020-06-23 | — | — | US | disclosed |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2019-06-13 | — | — | US | disclosed |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | THE UNIVERSITY OF TOKYO (JP) | 2019-06-13 | — | — | US | disclosed |
| WO-2017217439-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | 国立大学法人東京大学 | 2017-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689394-B2 | Thieno[2,3-b]pyridine derivative, quinoline derivative, and use thereof | BRD4, DRD4, TH | LIMK1 4598/4885HSP90AA1 3309/4885HSP90AB1 2807/4885 |
| US-20190177336-A1 | THIENO[2,3-b]PYRIDINE DERIVATIVE AND QUINOLINE DERIVATIVE, AND USE THEREOF | DERL1, UBQLN1, ADRM1 | LIMK1 3789/4885HSP90AA1 1146/4885HSP90AB1 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.