Sugi Predict

Sugi Predict / Compounds / SCHEMBL1977147

SCHEMBL1977147

SCHEMBL1977147

O=C1OCc2c[c]ccc21

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 8/20 0.61
▸ MAOB P27338 7/20 0.61
▸ MAPT P10636 2/20 0.52
▸ LMNA P02545 2/20 0.52
▸ GAA P10253 1/20 0.52
▸ ALDH1A1 P00352 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.47
▸ TYMS P04818 1/20 0.47
▸ CYP1A2 P05177 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ CYP2C19 P33261 1/20 0.47
▸ HSD17B10 Q99714 1/20 0.47
▸ PRF1 P14222 4/20 0.42
▸ RECQL P46063 1/20 0.42
▸ KCNJ1 P48048 1/20 0.38
▸ KCNH2 Q12809 1/20 0.38
▸ CYP3A4 P08684 1/20 0.38
▸ GFER P55789 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1450927 0.86 MAOA (0.57) MAOAMAOBMAPTLMNAGAA
SCHEMBL3622863 0.81 MAOA (0.42) MAOAMAOBMAPTLMNAGAA
Water SCHEMBL11007472 0.79 MAOA (0.95) MAOAMAOBMAPTLMNAGAA
SCHEMBL6903786 0.76 MAOA (1.00) MAOAMAOBMAPTLMNAGAA
SCHEMBL22284 0.76 MAOA (1.00) MAOAMAOBMAPTLMNAGAA
SCHEMBL6353583 0.76 MAOA (1.00) MAOAMAOBMAPTLMNAGAA
SCHEMBL29448271 0.76 MAOA (1.00) MAOAMAOBMAPTLMNAGAA
SCHEMBL11522370 0.76 MAOA (1.00) MAOAMAOBMAPTLMNAGAA
SCHEMBL1461403 0.76 MAOA (0.36) MAOAMAOBMAPTALDH1A1KDM4E
Benzene SCHEMBL18492989 0.74 MAOA (0.95) MAOAMAOBMAPTLMNAGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 127 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230310413-A1 PHARMACEUTICAL FORMULATIONS COMPRISING A MALT1 INHIBITOR AND A MIXTURE OF POLYETHYLENE GLYCOL WITH A FATTY ACID JANSSEN PHARMACEUTICA NV (BE) 2023-10-05 — — US claimed
CN-115884773-A Pharmaceutical preparation 詹森药业有限公司 2023-03-31 — — CN claimed
CN-115210567-A Methods of assessing efficacy of MALT1 inhibitors using NF-KB translocation assays 詹森药业有限公司 2022-10-18 — — CN claimed
EP-4062175-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY Janssen Pharmaceutica NV (BE) 2022-09-28 — — EP claimed
EP-4061966-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS Janssen Pharmaceutica NV (BE) 2022-09-28 — — EP claimed
CN-114981453-A NF-KB regulated gene expression assay for assessing efficacy of MALT1 inhibitors 詹森药业有限公司 2022-08-30 — — CN claimed
US-20220175760-A1 PHARMACEUTICAL FORMULATIONS JANSSEN PHARMACEUTICA NV (BE) 2022-06-09 — — US claimed
EP-3927324-A1 PHARMACEUTICAL FORMULATIONS Janssen Pharmaceutica NV (BE) 2021-12-29 — — EP claimed
CN-113473971-A Pharmaceutical formulations 詹森药业有限公司 2021-10-01 — — CN claimed
US-20210156865-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 — — US claimed
EP-1713465-A4 COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS IRM LLC (BM) 2009-04-22 — — EP claimed
US-20070293547-A1 Compounds and Compositions as Lxr Modulators IRM LLC (BM) 2007-12-20 — — US claimed
US-7186710-B2 Phthalazinones ALTANA PHARMA AG (DE) 2007-03-06 — — US claimed
EP-1713465-A2 COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS IRM LLC (BM) 2006-10-25 — — EP claimed
WO-2005077122-A2 COMPOUNDS AND COMPOSITIONS AS LXR MODULATORS IRM LLC (BM) 2005-08-25 — — WO claimed
US-20040127707-A1 PDE4/7 inhibitors useful in treatment of airway disorders, autoimmune system disorders, skin disorders, arthritis, nerve system disorders ALTANA PHARMA AG (DE) 2004-07-01 — — US claimed
EP-1385848-A2 PHTALAZINONES DERIVATIVES USEFUL AS PDE4/7 INHIBITORS ALTANA Pharma AG (DE) 2004-02-04 — — EP claimed
WO-2002085906-A2 PHTHALAZINONES DERIVATIVES USEFUL AS PDE4/7 INHIBITORS ALTANA PHARMA AG (DE) 2002-10-31 — — WO claimed
US-5723586-A ISOINDOLE OR BENZOISOTHIAZOLE DYES; WASH- AND COLORFASTNESS; DIAZOTIZATION CLARIANT FINANCE (BVI) LIMITED (VG) 1998-03-03 — — US claimed
US-5633355-A DISPERSE DYES SANDOZ LTD. (CH) 1997-05-27 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040127707-A1 PDE4/7 inhibitors useful in treatment of airway disorders, autoimmune system disorders, skin disorders, arthritis, nerve system disorders PDE4A, PDE4B, PDE7B MAOA 974/4885MAOB 994/4885MAPT 3506/4885
US-20230310413-A1 PHARMACEUTICAL FORMULATIONS COMPRISING A MALT1 INHIBITOR AND A MIXTURE OF POLYETHYLENE GLYCOL WITH A FATTY ACID MALT1, MGAM, MGLL MAOA 3630/4885MAOB 3990/4885MAPT 887/4885
US-20220175760-A1 PHARMACEUTICAL FORMULATIONS TREH, F12, CEL MAOA 732/4885MAOB 617/4885MAPT 62/4885
US-20070293547-A1 Compounds and Compositions as Lxr Modulators NR1H2, NR1H3, NR1H4 MAOA 4177/4885MAOB 3922/4885MAPT 3347/4885
US-20210156865-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY NFKBIA, MALT1, NFATC1 MAOA 4612/4885MAOB 3789/4885MAPT 2441/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.