Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19781532 | 0.89 | ACP1 (0.46) | MAPTTP53GLAACACBACACA | |
| SCHEMBL19781139 | 0.77 | ACP1 (0.41) | MAPTTP53HDAC3HDAC1HDAC2 | |
| SCHEMBL30837260 | 0.76 | KMT2A (0.63) | MAPTGLAACACBACACALMNA | |
| SCHEMBL19781791 | 0.76 | ACP1 (0.40) | MAPTTP53AKR1C3AKR1C2GLA | |
| SCHEMBL103890 | 0.71 | KMT2A (0.70) | MAPTTP53GLALMNAALDH1A1 | |
| SCHEMBL3717485 | 0.71 | KMT2A (0.49) | MAPTTP53AKR1C3AKR1C2GLA | |
| SCHEMBL19781774 | 0.70 | ACP1 (0.45) | MAPTTP53GLAACACBACACA | |
| SCHEMBL4105007 | 0.70 | GLA (0.61) | MAPTTP53GLALMNAHTT | |
| SCHEMBL4215577 | 0.69 | AKR1C3 (0.52) | MAPTAKR1C3AKR1C2RXRARXRB | |
| SCHEMBL185920 | 0.68 | ALDH1A1 (0.56) | MAPTAKR1C3AKR1C2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018013430-A2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION | ARISAN THERAPEUTICS INC. (US) | 2018-01-18 | — | — | WO | disclosed |