Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20985980 | 0.86 | TGFBR1 (0.34) | TGFBR1TSHRKDM4ENPC1ALDH1A1 | |
| SCHEMBL407720 | 0.81 | TRPA1 (0.33) | TRPA1 | |
| SCHEMBL22072385 | 0.81 | GABRA1 (0.37) | TGFBR1KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL24460464 | 0.79 | PIK3CA (0.39) | TGFBR1KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL19781568 | 0.79 | NOS3 (0.33) | TGFBR1KDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL20049572 | 0.78 | NPC1 (0.33) | TGFBR1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20049571 | 0.78 | PRMT5 (0.32) | TGFBR1 | |
| SCHEMBL1870362 | 0.78 | PIK3CB (0.32) | TRPA1ALDH1A1 | |
| SCHEMBL31646997 | 0.78 | SCN5A (0.40) | TRPA1 | |
| SCHEMBL24215339 | 0.77 | PDE10A (0.41) | TGFBR1KDM4ENPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022108849-A1 | HETEROCYCLIC COMPOUNDS AS THERAPEUTIC AGENTS | ARISAN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2020117794-A1 | COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION | ARISAN THERAPEUTICS, INC. (US) | 2020-06-11 | — | — | WO | disclosed |
| WO-2018013430-A2 | HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION | ARISAN THERAPEUTICS INC. (US) | 2018-01-18 | — | — | WO | disclosed |