Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | CES1 | P23141 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10723714 | 0.89 | SRD5A2 (0.83) | POLBSRD5A2LMNAGAAL3MBTL1 | |
| SCHEMBL975118 | 0.89 | SRD5A2 (0.83) | POLBSRD5A2LMNAGAAL3MBTL1 | |
| SCHEMBL6161137 | 0.87 | MEN1 (0.62) | POLBMEN1KMT2ASRD5A2LMNA | |
| 4-Nitrobenzoic Acid SCHEMBL8674796 | 0.86 | TDP1 (0.81) | POLBMEN1KMT2ASRD5A2MAPK1 | |
| SCHEMBL85535 | 0.85 | MEN1 (0.64) | POLBMEN1KMT2ALMNACES1 | |
| SCHEMBL28914440 | 0.83 | MAPK1 (0.85) | POLBSRD5A2LMNAGAAL3MBTL1 | |
| SCHEMBL8674798 | 0.83 | KMT2A (0.65) | POLBMEN1KMT2AMAPK1CES1 | |
| SCHEMBL1982760 | 0.83 | GSK3B (0.66) | POLBMEN1KMT2ASRD5A2MAPK1 | |
| SCHEMBL3571484 | 0.83 | CES2 (0.62) | POLBMEN1KMT2ALMNAGAA | |
| SCHEMBL29768853 | 0.83 | CES2 (0.62) | POLBMEN1KMT2ALMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113354629-B | Diaryl ethylene-naphthopyran dual photochromic compound and preparation method and application thereof | 天津孚信阳光科技有限公司 | 2022-11-25 | — | — | CN | disclosed |
| EP-3649110-B1 | MYCOBACTERIUM-TUBERCOLOSIS-THIOREDOXIN REDUCTASE INHIBITOR AS ANTITUBERCULOSIS DRUG | UNIV DORTMUND TECH (DE) | 2021-09-08 | — | — | EP | disclosed |
| US-11078185-B2 | Mycobacterium tuberculosis—thioredoxin reductase inhibitor as an antitubercular agent | TECHNISCHE UNIVERSITAT DORTMUND (DE) | 2021-08-03 | — | — | US | disclosed |
| EP-3649110-A1 | MYOBACTERIUM TUBERCULOSIS-THIOREDOXIN REDUCTASE INHIBITOR AS AN ANTITUBERCULAR AGENT | Technische Universität Dortmund (DE) | 2020-05-13 | — | — | EP | disclosed |
| US-20200123130-A1 | Myobacterium Tuberculosis-Thioredoxin Reductase Inhibitor as an Antitubercular Agent | TECHNISCHE UNIVERSITAT DORTMUND (DE) | 2020-04-23 | — | — | US | disclosed |
| WO-2019007710-A1 | MYOBACTERIUM TUBERCULOSIS-THIOREDOXIN REDUCTASE INHIBITOR AS AN ANTITUBERCULAR AGENT | TECHNISCHE UNIVERSITÄT DORTMUND (DE) | 2019-01-10 | — | — | WO | disclosed |
| EP-3424906-A1 | MYCOBACTERIUM-TUBERCOLOSIS-THIOREDOXIN REDUCTASE INHIBITOR AS ANTITUBERCULOSIS DRUG | Technische Universität Dortmund (DE) | 2019-01-09 | — | — | EP | disclosed |
| US-20160250187-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LTD (GB) | 2016-09-01 | — | — | US | disclosed |
| US-9283226-B2 | Pyrazole derivatives as protein kinase modulators | ASTEX THERAPEUTICS LIMITED (GB) | 2016-03-15 | — | — | US | disclosed |
| US-20140271662-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LTD (GB) | 2014-09-18 | — | — | US | disclosed |
| US-20070032478-A1 | Kinase Inhibitors | ALLERGAN, INC. | 2007-02-08 | — | — | US | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |
| WO-2007008895-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2007-01-18 | — | — | WO | disclosed |
| WO-2006136821-A1 | PHARMACEUTICAL COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006136837-A2 | PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2006-12-28 | — | — | WO | disclosed |
| EP-1706385-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | Astex Therapeutics Limited (GB) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005061463-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2005-07-07 | — | — | WO | disclosed |
| US-5599993-A | USED FOR ENDCAPPING POLYIMIDES WITH EXCELLENT SOLVENT AND CHEMICAL RESISTANCE, HIGH STRENGTH AND MODULUS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1997-02-04 | — | — | US | disclosed |
| US-5412066-A | Adhesives | THER UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) | 1995-05-02 | — | — | US | disclosed |
| US-4352942-A | TREATMENT OF ISOMERIC MIXTURE OF NITRO AROMATIC KETO COMPOUNDS WITH OLEUM | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1982-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123130-A1 | Myobacterium Tuberculosis-Thioredoxin Reductase Inhibitor as an Antitubercular Agent | TXNRD1, TXNRD3, TXNRD2 | POLB 1169/4885MEN1 2540/4885KMT2A 3070/4885 |
| US-20140271662-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | GRK3, GRK2, NR0B2 | POLB 2473/4885MEN1 3759/4885KMT2A 1820/4885 |
| US-20160250187-A1 | PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS | GRK3, GRK2, NR0B2 | POLB 2473/4885MEN1 3759/4885KMT2A 1820/4885 |
| US-20070032478-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | POLB 1863/4885MEN1 2293/4885KMT2A 1569/4885 |
| US-11078185-B2 | Mycobacterium tuberculosis—thioredoxin reductase inhibitor as an antitubercular agent | TXNRD3, TXNRD1, TXN | POLB 1960/4885MEN1 3557/4885KMT2A 2511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.