SCHEMBL1979649

SCHEMBL1979649

CCOC(=O)C(=O)c1ccc2c(c1)c1cc(C(=O)C(=O)OCC)ccc1n2CC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.51
HPGD P15428 3/20 0.51
HTT P42858 1/20 0.51
MAPT P10636 3/20 0.51
MAPK1 P28482 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
L3MBTL1 Q9Y468 1/20 0.51
ALDH1A1 P00352 5/20 0.48
TSHR P16473 1/20 0.48
HSD17B10 Q99714 1/20 0.48
DHODH Q02127 1/20 0.47
LMNA P02545 1/20 0.46
PPARG P37231 1/20 0.45
RAB9A P51151 1/20 0.45
NCOA2 Q15596 1/20 0.45
NCOA1 Q15788 1/20 0.45
PTGER4 P35408 1/20 0.43
RORC P51449 1/20 0.43
TUBB4A P04350 1/20 0.43
TUBB P07437 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13640249 0.94 KDM4E (0.50) KDM4EHPGDHTTMAPTMAPK1
SCHEMBL21636235 0.93 KDM4E (0.61) KDM4EHPGDMAPTMAPK1NPSR1
SCHEMBL18019122 0.87 LMNA (0.50) KDM4EHPGDHTTMAPTMAPK1
SCHEMBL21636281 0.87 KDM4E (0.49) KDM4EHPGDHTTMAPTMAPK1
SCHEMBL18016982 0.83 LMNA (0.46) KDM4EHPGDHTTMAPTMAPK1
SCHEMBL23533414 0.82 KMT2A (0.45) KDM4EHPGDHTTMAPTMAPK1
SCHEMBL13640231 0.81 KDM4E (0.57) KDM4EHPGDHTTMAPTMAPK1
SCHEMBL12596935 0.80 HCAR3 (0.40) KDM4EHPGDHTTMAPTMAPK1
SCHEMBL5797538 0.79 MAPT (0.55) KDM4EHPGDHTTMAPTALDH1A1
SCHEMBL12598588 0.79 ALDH1A1 (0.50) KDM4EHPGDHTTMAPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2509948-B1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA GRAPHICS NV (BE) 2017-05-03 EP disclosed
EP-2509948-B1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA GRAPHICS NV (BE) 2017-05-03 EP disclosed
US-8957224-B2 Photoinitiators for UV-LED curable compositions and inks AGFA GRAPHICS NV (BE) 2015-02-17 US disclosed
US-8957224-B2 Photoinitiators for UV-LED curable compositions and inks AGFA GRAPHICS NV (BE) 2015-02-17 US disclosed
US-8957224-B2 Photoinitiators for UV-LED curable compositions and inks AGFA GRAPHICS NV (BE) 2015-02-17 US disclosed
US-8569393-B2 UV-LED curable compositions and inks AGFA-GEVAERT N.V. (BE) 2013-10-29 US disclosed
US-20120309861-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-12-06 US disclosed
US-20120309861-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-12-06 US disclosed
US-20120309861-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-12-06 US disclosed
US-20120283349-A1 UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT N.V. (BE) 2012-11-08 US disclosed
EP-2509948-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS Agfa-Gevaert (BE) 2012-10-17 EP disclosed
WO-2011069947-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS AGFA-GEVAERT (BE) 2011-06-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120309861-A1 PHOTOINITIATORS FOR UV-LED CURABLE COMPOSITIONS AND INKS WEE1, CBX4, USP9X KDM4E 1156/4885HPGD 3146/4885HTT 587/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.