Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21980926 | 0.89 | PKM (0.43) | PKMKMT2AMEN1PABPC1HTR2C | |
| SCHEMBL1980368 | 0.84 | KEAP1 (0.48) | PKMKMT2AMEN1HTR2CALDH1A1 | |
| SCHEMBL1982716 | 0.83 | MEN1 (0.44) | PKMKMT2AMEN1PABPC1HTR2C | |
| SCHEMBL13268427 | 0.83 | KMT2A (0.43) | PKMKMT2AMEN1PABPC1HTR2C | |
| SCHEMBL1980327 | 0.81 | HTR2C (0.42) | PKMKMT2AMEN1HTR2CALDH1A1 | |
| SCHEMBL1983453 | 0.81 | ALDH1A1 (0.42) | PKMKMT2AMEN1PABPC1HTR2C | |
| SCHEMBL12594071 | 0.81 | MEN1 (0.40) | PKMKMT2AMEN1PABPC1HTR2C | |
| SCHEMBL13721666 | 0.80 | PKM (0.41) | PKMKMT2AMEN1PABPC1HTR2C | |
| SCHEMBL1980046 | 0.78 | HTR2C (0.43) | PKMKMT2AMEN1PABPC1HTR2C | |
| SCHEMBL1978975 | 0.76 | RAB9A (0.48) | PKMKMT2AMEN1HTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509961-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | Autifony Therapeutics Limited (GB) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011069951-A1 | IMIDAZOLIDINEDIONE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |