Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19806047 | 0.80 | ALDH1A1 (0.44) | ALDH1A1HTTMAOBKDM4EKMT2A | |
| SCHEMBL21019859 | 0.76 | ALDH1A1 (0.51) | ALDH1A1HTTKDM4EKMT2AMEN1 | |
| SCHEMBL1456221 | 0.75 | NNMT (0.46) | ALDH1A1HTTMAOBKDM4ENPC1 | |
| SCHEMBL13052047 | 0.74 | ALDH1A1 (0.42) | ALDH1A1HTTMAOBKDM4ENPC1 | |
| SCHEMBL2131428 | 0.74 | ALDH1A1 (0.70) | ALDH1A1HTTKDM4ENPC1RAB9A | |
| SCHEMBL12408679 | 0.69 | MEN1 (0.70) | ALDH1A1HTTKDM4ENPC1RAB9A | |
| SCHEMBL2986102 | 0.69 | HSP90AA1 (0.68) | ALDH1A1KDM4EKMT2AMEN1HSP90AA1 | |
| SCHEMBL29228586 | 0.68 | ALDH1A1 (0.62) | ALDH1A1HTTKDM4ENPC1RAB9A | |
| SCHEMBL3556326 | 0.67 | KMO (0.57) | ALDH1A1HTTKDM4ENPC1RAB9A | |
| SCHEMBL21019881 | 0.67 | ALDH1A1 (0.41) | ALDH1A1HTTKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-11725000-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2023-08-15 | — | — | US | disclosed |
| US-20210309647-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-10-07 | — | — | US | disclosed |
| US-11034680-B2 | Apoptosis inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2021-06-15 | — | — | US | disclosed |
| US-20190152960-A1 | Apoptosis Inhibitors | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2019-05-23 | — | — | US | disclosed |
| WO-2018014802-A1 | APOPTOSIS INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152960-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | ALDH1A1 550/4885HTT 788/4885MAOB 585/4885 |
| US-11725000-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | ALDH1A1 550/4885HTT 788/4885MAOB 585/4885 |
| US-11034680-B2 | Apoptosis inhibitors | BAX, SDHA, SDHB | ALDH1A1 550/4885HTT 788/4885MAOB 585/4885 |
| US-20210309647-A1 | Apoptosis Inhibitors | BAX, SDHA, SDHB | ALDH1A1 550/4885HTT 788/4885MAOB 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.