Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP7 | P55210 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19229905 | 0.82 | GRM1 (0.39) | SLC6A3KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL19807527 | 0.78 | SLC6A3 (0.33) | SLC6A3TSHRCHRNB2CHRNA4 | |
| SCHEMBL19807406 | 0.78 | SLC6A3 (0.33) | SLC6A3TSHRCHRNB2CHRNA4 | |
| SCHEMBL3926283 | 0.71 | SLC6A3 (0.40) | KCNH2SLC6A3SLC6A4KDM4EALDH1A1 | |
| SCHEMBL29723645 | 0.71 | SLC6A3 (0.40) | KCNH2SLC6A3SLC6A4KDM4EALDH1A1 | |
| SCHEMBL29723671 | 0.71 | SLC6A3 (0.40) | KCNH2SLC6A3SLC6A4KDM4EALDH1A1 | |
| SCHEMBL31064743 | 0.71 | SLC6A3 (0.40) | KCNH2SLC6A3SLC6A4KDM4EALDH1A1 | |
| SCHEMBL996860 | 0.71 | SLC6A3 (0.40) | KCNH2SLC6A3SLC6A4KDM4EALDH1A1 | |
| SCHEMBL6068737 | 0.70 | CHRNB2 (0.43) | SLC6A3SLC6A4KDM4EALDH1A1ATM | |
| SCHEMBL11239464 | 0.69 | SLC6A3 (0.53) | SLC6A3SLC6A4ALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399994-B2 | Compounds and methods for preventing or treating sensory hair cell death | UNIVERSITY OF WASHINGTON (US) | 2019-09-03 | — | — | US | disclosed |
| US-20180022756-A1 | COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH | FRED HUTCHINSON CANCER CENTER | 2018-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10399994-B2 | Compounds and methods for preventing or treating sensory hair cell death | CASP3, AIFM1, ATP6V1B1 | KCNH2 1453/4885SLC6A3 1936/4885SLC6A4 2507/4885 |
| US-20180022756-A1 | COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH | CASP3, AIFM1, ATP6V1B1 | KCNH2 1453/4885SLC6A3 1936/4885SLC6A4 2507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.