Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197703 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL395419 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL392365 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6239351 | 0.84 | CHRM1 (0.40) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6240565 | 0.81 | CA2 (0.41) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL3837519 | 0.77 | TDP1 (0.42) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL687714 | 0.77 | TDP1 (0.42) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6234803 | 0.75 | CTSS (0.34) | — | |
| SCHEMBL16667373 | 0.74 | TP53 (0.38) | OR51E2 | |
| SCHEMBL1406003 | 0.74 | TP53 (0.38) | OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 108 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160355801-A1 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | VERENIUM CORPORATION | 2016-12-08 | — | — | US | claimed |
| US-9315792-B2 | Nitrilases, nucleic acids encoding them and methods for making and using them | BASF ENZYMES LLC (US) | 2016-04-19 | — | — | US | claimed |
| EP-2327766-B1 | Nitrilases | BASF ENZYMES LLC (US) | 2015-12-02 | — | — | EP | claimed |
| EP-2319919-B1 | Nitrilases | BASF ENZYMES LLC (US) | 2015-08-12 | — | — | EP | claimed |
| US-20150125928-A1 | NITRILASES, NUCLEIC ACIDS ENCODING THEM AND METHODS FOR MAKING AND USING THEM | BASF ENZYMES LLC | 2015-05-07 | — | — | US | claimed |
| EP-2327767-B1 | Nitrilases | BASF ENZYMES LLC (US) | 2015-04-29 | — | — | EP | claimed |
| EP-2327765-B1 | Nitrilases | BASF ENZYMES LLC (US) | 2015-04-01 | — | — | EP | claimed |
| US-20130177949-A1 | NITRILASES | VERENIUM CORPORATION (US) | 2013-07-11 | — | — | US | claimed |
| US-20130130333-A1 | Processes for Making (R)-Ethyl 4-Cyano-3 Hydroxybutyric Acid | VERENIUM CORPORATION (US) | 2013-05-23 | — | — | US | claimed |
| US-8372608-B2 | Processes for making [R]-ethyl 4-cyano-3 hydroxybutyric acid | VERENIUM CORPORATION (US) | 2013-02-12 | — | — | US | claimed |
| EP-2327767-A1 | Nitrilases | Verenium Corporation (US) | 2011-06-01 | — | — | EP | claimed |
| EP-2327766-A1 | Nitrilases | Verenium Corporation (US) | 2011-06-01 | — | — | EP | claimed |
| EP-2319919-A1 | Nitrilases | Verenium Corporation (US) | 2011-05-11 | — | — | EP | claimed |
| US-7932064-B2 | Converting epichlorohydrin to 3-hydroxyglutaronitrile, catalyzing the conversion of the 3-hydroxyglutaronitrile to 4-cyano-3-hydroxybutyric acid by contacting with polypeptide having a nitrilase activity; intermediate for atorvastatin | VERENIUM CORPORATION (US) | 2011-04-26 | — | — | US | claimed |
| US-7811804-B2 | synthetic or recombinant polypeptide having a nitrilase activity; have increased activity and stability at increased pH and temperature | VERENIUM CORPORATION (US) | 2010-10-12 | — | — | US | claimed |
| US-20100216214-A1 | hydrolysis of a hydroxyglutaryl nitrile to generate an ethyl 4-cyano-3-hydroxybutyrate; hydrolysis of a mandelonitrile to generate a mandelic acid; hydrolysis of phenyllactocyanonitrile to generate an (S)-phenyllactic acid | VERENIUM CORPORATION (US) | 2010-08-26 | — | — | US | claimed |
| US-7521216-B2 | Nitrilases and methods for making and using them | VERENIUM CORPORATION (US) | 2009-04-21 | — | — | US | claimed |
| EP-2039762-A2 | Nitralases | Verenium Corporation (US) | 2009-03-25 | — | — | EP | claimed |
| US-20040053378-A1 | Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid | DIVERSA CORPORATION (US) | 2004-03-18 | — | — | US | claimed |
| WO-2003106415-A2 | PROCESSES FOR MAKING (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRIC ACID | DIVERSA CORPORATION (US) | 2003-12-24 | — | — | WO | claimed |