Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197703 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL395419 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL198107 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6239351 | 0.84 | CHRM1 (0.40) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6240565 | 0.81 | CA2 (0.41) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL3837519 | 0.77 | TDP1 (0.42) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL687714 | 0.77 | TDP1 (0.42) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6234803 | 0.75 | CTSS (0.34) | — | |
| SCHEMBL16667373 | 0.74 | TP53 (0.38) | OR51E2 | |
| SCHEMBL1406003 | 0.74 | TP53 (0.38) | OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208259-A1 | Halohydrin Dehalogenases and Related Polynucleotides | CODEXIS, INC. (US) | 2012-08-16 | — | — | US | claimed |
| EP-1727795-B1 | PROCESS FOR THE PRODUCTION OF ATORVASTATIN CALCIUM IN AMORPHOUS FORM | RANBAXY LAB LTD (IN) | 2012-02-15 | — | — | EP | claimed |
| US-7932064-B2 | Converting epichlorohydrin to 3-hydroxyglutaronitrile, catalyzing the conversion of the 3-hydroxyglutaronitrile to 4-cyano-3-hydroxybutyric acid by contacting with polypeptide having a nitrilase activity; intermediate for atorvastatin | VERENIUM CORPORATION (US) | 2011-04-26 | — | — | US | claimed |
| US-7521216-B2 | Nitrilases and methods for making and using them | VERENIUM CORPORATION (US) | 2009-04-21 | — | — | US | claimed |
| EP-2874992-B1 | PROCESS FOR CROSSED CLAISEN CONDENSATION REACTIONS PROMOTED BY LITHIUM AMIDE IN LIQUID AMMONIA | BAKHU LTD (GB) | 2020-04-15 | — | — | EP | disclosed |
| US-20150197476-A1 | PROCESS FOR CROSSED CLAISEN CONDENSATION REACTIONS PROMOTED BY LITHIUM AMIDE IN LIQUID AMMONIA | BAKHU PHARMA LTD (GB) | 2015-07-16 | — | — | US | disclosed |
| EP-2874992-A1 | PROCESS FOR CROSSED CLAISEN CONDENSATION REACTIONS PROMOTED BY LITHIUM AMIDE IN LIQUID AMMONIA | Bakhu Pharma Limited (GB) | 2015-05-27 | — | — | EP | disclosed |
| CN-104357468-A | Parvibaculum lavamentivorans ZJB 14001, halohydrin dehalogenase enzyme gene, enzyme, engineered bacterium and application | UNIV ZHEJIANG TECHNOLOGY | 2015-02-18 | — | — | CN | disclosed |
| US-20140051869-A1 | CONTINUOUS PROCESS FOR THE PRODUCTION OF BETA-KETO ESTERS BY CLAISEN CONDENSATION | PHOENIX CHEMICALS LIMITED (GB) | 2014-02-20 | — | — | US | disclosed |
| WO-2014013261-A1 | PROCESS FOR CROSSED CLAISEN CONDENSATION REACTIONS PROMOTED BY LITHIUM AMIDE IN LIQUID AMMONIA | BAKHU PHARMA LIMITED (GB) | 2014-01-23 | — | — | WO | disclosed |
| US-8535910-B2 | Halohydrin dehalogenases and related polynucleotides | CODEXIS, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20130130333-A1 | Processes for Making (R)-Ethyl 4-Cyano-3 Hydroxybutyric Acid | VERENIUM CORPORATION (US) | 2013-05-23 | — | — | US | disclosed |
| US-20040137585-A1 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives | CODEXIS, INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004027075-A2 | CHEMOENZYMATIC METHODS FOR THE SYNTHESIS OF STATINS AND STAIN INTERMEDIATES | DIVERSA CORPORATION (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20040053378-A1 | Processes for making (R)-ethyl 4-cyano-3-hydroxybutyric acid | DIVERSA CORPORATION (US) | 2004-03-18 | — | — | US | disclosed |
| WO-2004015132-A2 | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | CODEXIS, INC. (US) | 2004-02-19 | — | — | WO | disclosed |
| WO-2003106415-A2 | PROCESSES FOR MAKING (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRIC ACID | DIVERSA CORPORATION (US) | 2003-12-24 | — | — | WO | disclosed |
| WO-2003097581-A1 | CONTINUOUS PROCESS FOR THE CYANATION OF HYDROGENATED BETA-KETOESTERS | PHOENIX CHEMICALS LIMITED (GB) | 2003-11-27 | — | — | WO | disclosed |
| US-6603015-B2 | Antitumor agents; anticancer agents; malaria; Alzheimer's disease | UNIVERSITY OF KANSAS | 2003-08-05 | — | — | US | disclosed |
| US-20020156289-A1 | Synthesis of epothilones | THE UNIVERSITY OF KANSAS | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051869-A1 | CONTINUOUS PROCESS FOR THE PRODUCTION OF BETA-KETO ESTERS BY CLAISEN CONDENSATION | AKR1C4, AKR1C3, AKR1C2 | TDP1 4555/4885CHRM1 1989/4885AKR1A1 8/4885 |
| US-20150197476-A1 | PROCESS FOR CROSSED CLAISEN CONDENSATION REACTIONS PROMOTED BY LITHIUM AMIDE IN LIQUID AMMONIA | BCAT1, ELOVL3, COASY | TDP1 4523/4885CHRM1 3735/4885AKR1A1 749/4885 |
| US-20020156289-A1 | Synthesis of epothilones | ADH1C, ADH1A, ADH5 | TDP1 4423/4885CHRM1 1564/4885AKR1A1 33/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.