Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL197703 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL198107 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL392365 | 1.00 | TDP1 (0.33) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6239351 | 0.84 | CHRM1 (0.40) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6240565 | 0.81 | CA2 (0.41) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL3837519 | 0.77 | TDP1 (0.42) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL687714 | 0.77 | TDP1 (0.42) | TDP1CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL6234803 | 0.75 | CTSS (0.34) | — | |
| SCHEMBL16667373 | 0.74 | TP53 (0.38) | OR51E2 | |
| SCHEMBL1406003 | 0.74 | TP53 (0.38) | OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8535910-B2 | Halohydrin dehalogenases and related polynucleotides | CODEXIS, INC. (US) | 2013-09-17 | — | — | US | disclosed |
| US-20120208259-A1 | Halohydrin Dehalogenases and Related Polynucleotides | CODEXIS, INC. (US) | 2012-08-16 | — | — | US | disclosed |
| US-8101395-B2 | Halohydrin dehalogenases and related polynucleotides | CODEXIS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| EP-1537222-B1 | ENZYMATIC PROCESSES FOR THE PRODUCTION OF 4-SUBSTITUTED 3-HYDROXYBUTYRIC ACID DERIVATIVES | CODEXIS INC (US) | 2011-03-09 | — | — | EP | disclosed |