SCHEMBL198136

SCHEMBL198136

O=C(O)C[C@H](Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O)C(=O)O

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DNPH1 O43598 14/20 0.69
P2RY12 Q9H244 2/20 0.67
TAS1R3 Q7RTX0 2/20 0.66
TAS1R1 Q7RTX1 2/20 0.66
P2RY2 P41231 2/20 0.64
P2RY1 P47900 2/20 0.64
PRKAB2 O43741 1/20 0.64
TRPM2 O94759 1/20 0.64
LDHA P00338 1/20 0.64
ADRB2 P07550 1/20 0.64
FBP1 P09467 1/20 0.64
SRC P12931 1/20 0.64
ADORA1 P30542 1/20 0.64
PRKAG1 P54619 1/20 0.64
PRKAA2 P54646 1/20 0.64
PDE4D Q08499 1/20 0.64
KCNH2 Q12809 1/20 0.64
PRKAA1 Q13131 1/20 0.64
PDE3A Q14432 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23780814 1.00 DNPH1 (0.69) DNPH1P2RY12TAS1R3TAS1R1P2RY2
SCHEMBL23787292 1.00 DNPH1 (0.69) DNPH1P2RY12TAS1R3TAS1R1P2RY2
SCHEMBL23787291 1.00 DNPH1 (0.69) DNPH1P2RY12TAS1R3TAS1R1P2RY2
SCHEMBL23780817 1.00 DNPH1 (0.69) DNPH1P2RY12TAS1R3TAS1R1P2RY2
SCHEMBL23780815 0.86 ADORA3 (0.66) ADORA1SMN1; SMN2
SCHEMBL23780820 0.86 ADORA3 (0.66) ADORA1SMN1; SMN2
SCHEMBL23780816 0.86 ADORA3 (0.66) ADORA1SMN1; SMN2
SCHEMBL23787289 0.86 ADORA3 (0.66) ADORA1SMN1; SMN2
SCHEMBL23787290 0.86 ADORA3 (0.66) ADORA1SMN1; SMN2
SCHEMBL23780819 0.86 ADORA3 (0.66) ADORA1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 899 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4698663-A1 GENOME EDITING METHODS AND CONSTRUCTS Fondazione Telethon ETS (IT) 2026-02-25 EP claimed
US-20250288694-A1 HOMOLOGY INDEPENDENT TARGETED INTEGRATION FOR GENE EDITING FONDAZIONE TELETHON ETS (IT) 2025-09-18 US claimed
US-20250222140-A1 GENOME EDITING METHODS AND CONSTRUCTS FONDAZIONE TELETHON ETS (IT) 2025-07-10 US claimed
EP-4518907-A1 HOMOLOGY INDEPENDENT TARGETED INTEGRATION FOR GENE EDITING Fondazione Telethon ETS (IT) 2025-03-12 EP claimed
CN-119136844-A Homologous independent targeted integration for gene editing 泰莱托恩基金会第三部门组织 2024-12-13 CN claimed
WO-2024216536-A1 METHOD FOR PREPARING RIBONUCLEOSIDE OR DERIVATIVE THEREOF, AND BIOLOGICAL ENZYME PREPARATION AND APPLICATION THEREOF 百瑞全球有限公司 2024-10-24 WO claimed
WO-2024218394-A1 GENOME EDITING METHODS AND CONSTRUCTS FONDAZIONE TELETHON ETS (IT) 2024-10-24 WO claimed
EP-3542823-B1 INTRACELLULAR ATP ENHANCER STAGEN CO LTD (JP) 2024-03-13 EP claimed
WO-2024048514-A1 TESTING METHOD FOR CERVICAL CANCER AND/OR CERVICAL INTRAEPITHELIAL NEOPLASIA 学校法人藤田学園 2024-03-07 WO claimed
WO-2023213831-A1 HOMOLOGY INDEPENDENT TARGETED INTEGRATION FOR GENE EDITING FONDAZIONE TELETHON ETS (IT) 2023-11-09 WO claimed
EP-0813599-A1 PLANT ADENYLOSUCCINATE SYNTHETASE AND DNA CODING THEREFOR Novartis AG (CH) 1997-12-29 EP claimed
US-5688939-A Plant adenylosuccinate synthetase and DNA coding therefor NOVARTIS FINANCE CORPORATION 1997-11-18 US claimed
WO-1996034855-A1 FATTY ACID ESTERS AS BIOACTIVE COMPOUNDS SCOTIA HOLDINGS PLC (GB) 1996-11-07 WO claimed
WO-1996034846-A1 1,3-PROPANE DIOL DERIVATIVES AS BIOACTIVE COMPOUNDS SCOTIA HOLDINGS PLC (GB) 1996-11-07 WO claimed
WO-1996019576-A1 PLANT ADENYLOSUCCINATE SYNTHETASE AND DNA CODING THEREFOR NOVARTIS AG (CH) 1996-06-27 WO claimed
WO-1996018739-A1 PLANT ADENYLOSUCCINATE LYASE AND DNA CODING THEREFOR NOVARTIS AG (CH) 1996-06-20 WO claimed
US-5519125-A Plant adenylosuccinate synthetase and DNA coding therefor CIBA-GEIGY CORPORATION (US) 1996-05-21 US claimed
EP-0458519-A2 Synthesis of nucleotide and nucleoside derivatives EFAMOL HOLDINGS PLC (GB) 1991-11-27 EP claimed
EP-0286303-A1 DNA and its use Takeda Chemical Industries, Ltd. (JP) 1988-10-12 EP claimed
US-4578336-A ADENINE SOURCE TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1986-03-25 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250288694-A1 HOMOLOGY INDEPENDENT TARGETED INTEGRATION FOR GENE EDITING HAVCR2, HMGB3, FANCI DNPH1 1156/4885P2RY12 3611/4885TAS1R3 4660/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.