SCHEMBL1983443

SCHEMBL1983443

CC(=O)c1ccc2c(c1)N(C)c1ccccc1S2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOX1 Q9Y5S8 7/20 1.00
LMNA P02545 2/20 1.00
MAPT P10636 2/20 1.00
L3MBTL1 Q9Y468 2/20 1.00
MAPK1 P28482 1/20 1.00
TDP1 Q9NUW8 1/20 1.00
SLC6A2 P23975 4/20 0.61
SLC6A4 P31645 4/20 0.61
DRD3 P35462 4/20 0.61
HTR1A P08908 3/20 0.61
ADRA2A P08913 3/20 0.61
DRD2 P14416 3/20 0.61
ADRA1A P35348 3/20 0.61
SLC6A3 Q01959 3/20 0.61
KCNH2 Q12809 3/20 0.61
DRD1 P21728 2/20 0.61
CYP1A2 P05177 2/20 0.61
CHRM2 P08172 2/20 0.61
CYP2D6 P10635 2/20 0.61
CHRM1 P11229 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16492910 0.91 NOX1 (0.83) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL31425281 0.86 NOX1 (0.76) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL26787361 0.84 NOX1 (0.73) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL31389018 0.84 NOX1 (0.73) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL4622014 0.83 NOX1 (0.73) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL30725912 0.83 NOX1 (0.73) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL1984394 0.82 NOX1 (0.70) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL2669541 0.82 NOX1 (0.70) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL9475738 0.81 HTR1A (0.77) NOX1LMNAMAPTL3MBTL1MAPK1
SCHEMBL27573856 0.81 LMNA (0.68) NOX1LMNAMAPTL3MBTL1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070261806-A1 Treatment of Pulp Stocks Using Oxidative Enzymes to Reduce Pitch Deposition ENZYMATIC DEINKING TECHNOLOGIES, LLC 2007-11-15 US claimed
EP-0707637-B1 ENHANCEMENT OF LACCASE REACTIONS NOVOZYMES AS (DK) 2005-11-02 EP claimed
EP-1137391-B1 METHOD FOR TREATING HAIR NOVOZYMES AS (DK) 2004-11-03 EP claimed
US-20040049859-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method L'OREAL S.A. (FR) 2004-03-18 US claimed
US-20040025265-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method LANG GERARD (FR) 2004-02-12 US claimed
US-20030159706-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method L'OREAL S.A. (FR) 2003-08-28 US claimed
US-6572843-B1 Combining permanent dyeing and straightening; applying to reduced hair an oxidizing enzyme (Laccase), a mediator, and a chemical oxidizing agent that produces hydrogen peroxide NOVOZYMES, A/S (DK) 2003-06-03 US claimed
EP-1304996-A1 ENZYME COMPOSITION FOR BLEACHING HUMAN KERATINOUS FIBRES AND BLEACHING METHOD L'OREAL (FR) 2003-05-02 EP claimed
EP-1304997-A1 ENZYME COMPOSITION FOR BLEACHING HUMAN KERATINOUS FIBRES AND BLEACHING METHOD L'OREAL (FR) 2003-05-02 EP claimed
EP-1304998-A1 ENZYME COMPOSITION FOR BLEACHING HUMAN KERATINOUS FIBRES AND BLEACHING METHOD L'OREAL (FR) 2003-05-02 EP claimed
EP-0912097-A1 ANTIMICROBIAL PEROXIDASE COMPOSITIONS NOVO NORDISK A/S (DK) 1999-05-06 EP claimed
US-5899212-A CLEAVAGE OF DISULFIDE BONDS, OXIDOREDUCTASE NOVO NORDISK A/S (DK) 1999-05-04 US claimed
US-5885304-A AROMATIC COMPOUNDS CONTAINING AT LEAST TWO RINGS, AT LEAST ONE SUBSTITUTED WITH NITROGEN OXYGEN, OR SULFUR NOVO NORDISK A/S (DK) 1999-03-23 US claimed
US-5795855-A DETERGENTS NOVO NORDISK A/S 1998-08-18 US claimed
WO-1997042825-A1 ANTIMICROBIAL PEROXIDASE COMPOSITIONS NOVO NORDISK A/S (DK) 1997-11-20 WO claimed
CN-1126490-A Enhancement of laccase reactions NOVO NORDISK AS (DK) 1996-07-10 CN claimed
EP-0707637-A1 ENHANCEMENT OF LACCASE REACTIONS NOVO NORDISK A/S (DK) 1996-04-24 EP claimed
EP-0679183-A1 ENHANCEMENT OF ENZYME REACTIONS NOVO NORDISK A/S (DK) 1995-11-02 EP claimed
WO-1995001426-A1 ENHANCEMENT OF LACCASE REACTIONS NOVO NORDISK A/S (DK) 1995-01-12 WO claimed
WO-1994012621-A1 ENHANCEMENT OF ENZYME REACTIONS NOVO NORDISK (DK) 1994-06-09 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030159706-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method KRT18, LPO, MPO NOX1 32/4885LMNA 1343/4885MAPT 1208/4885
US-20040025265-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method KRT18, LPO, ALDH1A2 NOX1 185/4885LMNA 2377/4885MAPT 1295/4885
US-20040049859-A1 Enzyme composition for bleaching human keratinous fibres and bleaching method KRT18, COXFA4, LPO NOX1 186/4885LMNA 1636/4885MAPT 1092/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.