Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.39 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | GABRE | P78334 | 2/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18599000 | 0.95 | IMPDH2 (0.36) | IMPDH2IMPDH1ALDH1A1MEN1KMT2A | |
| SCHEMBL17826659 | 0.82 | KMT2A (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7835691 | 0.69 | CDC25A (0.45) | ALDH1A1TSHRMEN1ALOX15KMT2A | |
| SCHEMBL3281297 | 0.68 | TDP1 (0.36) | ALDH1A1CYP3A4KDM4EMEN1LMNA | |
| SCHEMBL22043212 | 0.68 | ALDH1A1 (0.38) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23052513 | 0.68 | CYP2C9 (0.35) | IMPDH2IMPDH1ALDH1A1KDM4EMEN1 | |
| SCHEMBL8613762 | 0.67 | — | — | |
| SCHEMBL28119464 | 0.67 | THRA (0.34) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18598999 | 0.67 | CTRC (0.38) | ALDH1A1KDM4ELMNAMAPTKMT2A | |
| SCHEMBL8998740 | 0.66 | GLA (0.37) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11192866-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-12-07 | — | — | US | disclosed |
| US-20190345116-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-11-14 | — | — | US | disclosed |
| US-9884830-B2 | Synthesis of tetracyclines and analogues thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11192866-B2 | Synthesis of tetracyclines and analogues thereof | TET1, TET3, MYC | IMPDH2 2220/4885IMPDH1 1595/4885GABRP 3958/4885 |
| US-20190345116-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | TET1, TET3, MYC | IMPDH2 2220/4885IMPDH1 1595/4885GABRP 3958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.