Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | BCHE | P06276 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | GBA1 | P04062 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13221522 | 0.86 | TSHR (0.55) | THRAPOLBTP53THRB | |
| SCHEMBL8477806 | 0.83 | MCHR1 (0.57) | DRD2BCHEACHEMAPTKDM4E | |
| SCHEMBL6539277 | 0.83 | TP53 (0.60) | THRATP53THRB | |
| SCHEMBL6057420 | 0.82 | ESR1 (0.59) | DRD2BCHEACHEMAPTALDH1A1 | |
| SCHEMBL15537810 | 0.81 | THRA (0.59) | BCHEACHEDRD3CYP2D6THRA | |
| SCHEMBL2953908 | 0.81 | MAPT (0.74) | DRD2BCHEACHEMAPTALDH1A1 | |
| SCHEMBL631252 | 0.80 | L3MBTL1 (0.70) | DRD2BCHEACHEMAPTALDH1A1 | |
| SCHEMBL1981044 | 0.80 | PKM (0.62) | DRD2BCHEACHEMAPTALDH1A1 | |
| SCHEMBL15069756 | 0.80 | KDM4E (0.47) | BCHEACHEALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL12315759 | 0.79 | ALDH1A1 (0.56) | DRD2BCHEACHEALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8263661-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-09-11 | — | — | US | disclosed |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-06-23 | — | — | US | disclosed |
| EP-1680101-A4 | DEVELOPMENT OF NEW SELECTIVE ESTROGEN RECEPTOR MODULATORS | UNIV CALIFORNIA OFFICE OF THE (US) | 2009-04-08 | — | — | EP | disclosed |
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2008-09-04 | — | — | US | disclosed |
| US-7196119-B2 | Development of new selective estrogen receptor modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-03-27 | — | — | US | disclosed |
| EP-1680101-A1 | DEVELOPMENT OF NEW SELECTIVE ESTROGEN RECEPTOR MODULATORS | The Regents of the University of California, Office of the President (US) | 2006-07-19 | — | — | EP | disclosed |
| US-20050113453-A1 | Development of new selective estrogen receptor modulators | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-05-26 | — | — | US | disclosed |
| WO-2005041946-A1 | DEVELOPMENT OF NEW SELECTIVE ESTROGEN RECEPTOR MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214609-A1 | Development of new selective estrogen receptor modulators | ESR2, ESR1, GPER1 | DRD2 2796/4885BCHE 2271/4885ACHE 3473/4885 |
| US-20050113453-A1 | Development of new selective estrogen receptor modulators | ESR2, ESR1, GPER1 | DRD2 2796/4885BCHE 2271/4885ACHE 3473/4885 |
| US-20110152226-A1 | Development of New Selective Estrogen Receptor Modulators | ESR2, ESR1, GPER1 | DRD2 2796/4885BCHE 2271/4885ACHE 3473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.