Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.48 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.48 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.48 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.48 |
| ▸ | MLYCD | O95822 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19853442 | 0.85 | TP53 (0.54) | RAB9AMAPTMEN1ALDH1A1GAA | |
| SCHEMBL21678101 | 0.84 | ALDH1A1 (0.56) | LMNARAB9AMEN1ALDH1A1KMT2A | |
| SCHEMBL11979758 | 0.83 | MAPK14 (0.76) | MAOAMAPK14LMNARAB9AMAPT | |
| SCHEMBL21678103 | 0.81 | PLAAT3 (0.58) | LMNAMAPTMEN1ALDH1A1KMT2A | |
| SCHEMBL19465495 | 0.81 | SMN1; SMN2 (0.61) | MAOAMAPK14LMNARAB9AMAPT | |
| SCHEMBL2634030 | 0.77 | MAPK14 (0.76) | MAOAMAPK14LMNARAB9ALSS | |
| SCHEMBL19465638 | 0.77 | LMNA (0.61) | MAOALMNARAB9AMAPTMEN1 | |
| SCHEMBL28499154 | 0.75 | ALDH1A1 (0.69) | MAPK14LMNARAB9AMAPTMEN1 | |
| SCHEMBL4617209 | 0.74 | PTPN1 (0.54) | MAOAMAPK14LMNARAB9AMAPT | |
| SCHEMBL16482894 | 0.73 | MAOA (1.00) | MAOAHDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11180748-B2 | Reagents and methods for esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2021-11-23 | — | — | US | disclosed |
| US-20200032238-A1 | Reagents and Methods for Esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2020-01-30 | — | — | US | disclosed |
| US-10428323-B2 | Reagents and methods for esterification | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2019-10-01 | — | — | US | disclosed |
| US-20180037881-A1 | Reagents and Methods for Esterification | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11180748-B2 | Reagents and methods for esterification | VIP, BCR, TMPO | MAOA 2805/4885MAPK14 1727/4885LMNA 734/4885 |
| US-10428323-B2 | Reagents and methods for esterification | VIP, BCR, TMPO | MAOA 2897/4885MAPK14 1836/4885LMNA 703/4885 |
| US-20180037881-A1 | Reagents and Methods for Esterification | VIP, BCR, TMPO | MAOA 2897/4885MAPK14 1836/4885LMNA 703/4885 |
| US-20200032238-A1 | Reagents and Methods for Esterification | VIP, BCR, TMPO | MAOA 2805/4885MAPK14 1727/4885LMNA 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.