Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 3/20 | 0.33 |
| ▸ | DRD3 | P35462 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | STAT6 | P42226 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | CYP51A1 | Q16850 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19856946 | 0.91 | DRD2 (0.38) | HCRTR1HCRTR2DRD4DRD3DRD2 | |
| SCHEMBL19856948 | 0.91 | DRD2 (0.38) | HCRTR1HCRTR2DRD4DRD3DRD2 | |
| SCHEMBL19856978 | 0.91 | DRD2 (0.39) | DRD4DRD3DRD2HTR1AHTR2A | |
| SCHEMBL19856980 | 0.91 | DRD2 (0.39) | DRD4DRD3DRD2HTR1AHTR2A | |
| SCHEMBL19856912 | 0.87 | ESR1 (0.40) | DRD4DRD3DRD2HTR1AHTR2A | |
| SCHEMBL19856911 | 0.87 | ESR1 (0.40) | DRD4DRD3DRD2HTR1AHTR2A | |
| SCHEMBL19856959 | 0.86 | ALOX15 (0.40) | DRD4DRD3DRD2HTR1AHTR2A | |
| SCHEMBL19856908 | 0.86 | ALOX15 (0.40) | DRD4DRD3DRD2HTR1AHTR2A | |
| SCHEMBL19856871 | 0.85 | DRD2 (0.41) | DRD2STAT6SMYD3CYP51A1TAS1R3 | |
| SCHEMBL19856872 | 0.85 | DRD2 (0.41) | DRD2STAT6SMYD3CYP51A1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925857-B1 | USE OF TRPV4 ANTAGONISTS TO AMELIORATE HYDROCEPHALUS AND RELATED MATERIALS AND METHODS | UNIV INDIANA RES & TECH CORP (US) | 2018-02-14 | — | — | EP | claimed |