Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 3/20 | 0.36 |
| ▸ | ALPL | P05186 | 3/20 | 0.36 |
| ▸ | XIAP | P98170 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30521624 | 0.84 | GRN (0.41) | ALDH1A1ENPP3ALPLXIAPLMNA | |
| SCHEMBL22577772 | 0.82 | HTR4 (0.52) | CDK8AURKACSF1RRETLTK | |
| SCHEMBL24371481 | 0.80 | GAA (0.40) | ALDH1A1HPGDLMNAHTR4KDM4E | |
| SCHEMBL22577770 | 0.74 | HTR4 (0.38) | HTR4KDM4EGAA | |
| SCHEMBL7947758 | 0.74 | ENPP3 (0.39) | ALDH1A1PARP1ENPP3ALPLXIAP | |
| SCHEMBL22235731 | 0.71 | IRAK4 (0.42) | CDK8AURKARETLTKCSNK1A1 | |
| SCHEMBL22582783 | 0.71 | TLR8 (0.40) | CDK8AURKACSF1RRETLTK | |
| SCHEMBL13908966 | 0.71 | ENPP3 (0.33) | ALDH1A1PARP1ENPP3ALPLXIAP | |
| SCHEMBL4035386 | 0.71 | AHR (0.35) | ALDH1A1HPGDPARP1ENPP3ALPL | |
| SCHEMBL5847269 | 0.71 | ENPP3 (0.33) | ALDH1A1PARP1ENPP3ALPLXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4188094-A1 | A PESTICIDALLY ACTIVE MIXTURE COMPRISING PYRAZOLOPYRIDINE ANTHRANILAMIDE COMPOUND, OXIDES OR SALTS THEREOF | PI Industries Ltd. (IN) | 2023-06-07 | — | — | EP | claimed |
| WO-2022023931-A1 | A PESTICIDALLY ACTIVE MIXTURE COMPRISING PYRAZOLOPYRIDINE ANTHRANILAMIDE COMPOUND, OXIDES OR SALTS THEREOF | PI INDUSTRIES LTD (IN) | 2022-02-03 | — | — | WO | claimed |
| EP-3728256-A1 | PYRAZOLOPYRIDINE-DIAMIDES, THEIR USE AS INSECTICIDE AND PROCESSES FOR PREPARING THE SAME | PI Industries Ltd. (IN) | 2020-10-28 | — | — | EP | claimed |
| US-12024510-B2 | Pyrazolopyridine-diamides, their use as insecticide and processes for preparing the same | PI INDUSTRIES LTD. (IN) | 2024-07-02 | — | — | US | disclosed |
| US-20200339578-A1 | PYRAZOLOPYRIDINE-DIAMIDES, THEIR USE AS INSECTICIDE AND PROCESSES FOR PREPARING THE SAME | PI INDUSTRIES LTD. (IN) | 2020-10-29 | — | — | US | disclosed |
| EP-3728256-A1 | PYRAZOLOPYRIDINE-DIAMIDES, THEIR USE AS INSECTICIDE AND PROCESSES FOR PREPARING THE SAME | PI Industries Ltd. (IN) | 2020-10-28 | — | — | EP | disclosed |
| US-10174005-B2 | Fused pyrimidines as inhibitors of p97 complex | CLEAVE BIOSCIENCES, INC. (US) | 2019-01-08 | — | — | US | disclosed |
| US-20180044325-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | CLEAVE BIOSCIENCES, INC. | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10174005-B2 | Fused pyrimidines as inhibitors of p97 complex | WDR77, POP1, PSMG3 | CDK8 1805/4885AURKA 935/4885CSF1R 4058/4885 |
| US-12024510-B2 | Pyrazolopyridine-diamides, their use as insecticide and processes for preparing the same | DDT, QDPR, CYP1A1 | CDK8 3528/4885AURKA 1860/4885CSF1R 3636/4885 |
| US-20180044325-A1 | FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX | WDR77, POP1, PSMG3 | CDK8 1789/4885AURKA 892/4885CSF1R 4058/4885 |
| US-20200339578-A1 | PYRAZOLOPYRIDINE-DIAMIDES, THEIR USE AS INSECTICIDE AND PROCESSES FOR PREPARING THE SAME | DDT, QDPR, CYP1A1 | CDK8 3528/4885AURKA 1860/4885CSF1R 3636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.